1380500-92-4 Usage
Description
2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetic acid, also known as Tetrazine-Acid, is a chemical compound that demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile. It is characterized by its fast reaction rate, which is the fastest reported for a bioorthogonal reaction. Despite having a lower chemical stability compared to methyltetrazines, it remains in an acceptable range for various applications.
Uses
Used in Bioorthogonal Chemistry:
2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetic acid is used as a key component in bioorthogonal chemistry for its exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile. This property allows for efficient and specific labeling of biomolecules in living systems without interfering with native biochemical reactions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetic acid can be used as a component in drug delivery systems, taking advantage of its fast reaction kinetics and bioorthogonal properties to improve the targeting and release of therapeutic agents.
Used in Chemical Synthesis:
2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetic acid can be employed as a building block or intermediate in the synthesis of various complex molecules, such as pharmaceuticals, agrochemicals, and advanced materials, due to its unique reactivity and bioorthogonal properties.
Used in Imaging Techniques:
In the field of molecular imaging, 2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetic acid can be utilized as a contrast agent or labeling moiety for visualizing specific biological processes or structures in living organisms, thanks to its fast reaction kinetics and bioorthogonal nature.
Check Digit Verification of cas no
The CAS Registry Mumber 1380500-92-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,5,0 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1380500-92:
(9*1)+(8*3)+(7*8)+(6*0)+(5*5)+(4*0)+(3*0)+(2*9)+(1*2)=134
134 % 10 = 4
So 1380500-92-4 is a valid CAS Registry Number.
1380500-92-4Relevant articles and documents
TRANS-CYCLOOCTENE LABELED ANTISENSE OLIGONUCLEOTIDES, RADIO LABELED TETRAZINE AND METHODS
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Page/Page column 46-47, (2021/02/26)
Featured are trans-cyclooctene and tetrazine compounds. Also provided are methods for evaluating the biodistribution and/or concentration of a biomolecule in a subject.
NOVEL TETRAZINES AND METHOD OF SYNTHESIZING THE SAME
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Paragraph 0293, (2013/10/22)
Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines and diazonorcaradienes.
