3473-63-0 Usage
Description
Formamidine acetate is a white to light yellow crystalline powder that serves as a versatile intermediate in the synthesis of various active pharmaceutical ingredients. It is also recognized for its role as a condensing agent in the preparation of specific chemical compounds.
Uses
Used in Pharmaceutical Industry:
Formamidine acetate is used as an intermediate for the synthesis of active pharmaceutical ingredients, contributing to the development of new drugs and therapies.
Used in Chemical Synthesis:
Formamidine acetate acts as a condensing agent in the preparation of pyrimidine and imidazole heterocycles, which are important structural components in various chemical and pharmaceutical applications.
Used in Solar Cell Technology:
Formamidine acetate salt is widely utilized in the preparation of formamidinium lead triiodide (FAPbI3) perovskites for perovskite solar cells, enhancing the efficiency and performance of these renewable energy devices.
Used in Display Applications:
In the field of display technology, formamidinium lead bromide nanocrystals synthesized using formamidine acetate salt are employed as emitters, contributing to the advancement of display devices with improved performance and quality.
Purification Methods
Unlike the hydrochloride, the acetate salt is not hygroscopic. It is recrystallised from a small volume of acetic acid, by addition of EtOH and the crystals are washed with EtOH then Et2O and dried in a vacuum. [Taylor et al. Org Synth 46 39 1966, Beilstein 2 IV 82.]
Check Digit Verification of cas no
The CAS Registry Mumber 3473-63-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,7 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3473-63:
(6*3)+(5*4)+(4*7)+(3*3)+(2*6)+(1*3)=90
90 % 10 = 0
So 3473-63-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)/p-1
3473-63-0Relevant articles and documents
Sustainable and cost-efficient electro-synthesis of formamidine acetate from cyanamide in aqueous acidic electrolyte
Güthner, Thomas,Klein, Martin,Sans, Jürgen,Thalhammer, Franz,Waldvogel, Siegfried R.
supporting information, p. 3289 - 3294 (2021/05/25)
Formamidine represents a versatile building block in synthetic organic chemistry. We developed a new electrochemical synthesis of formamidine acetate by cathodic reduction of cyanamide in an aqueous electrolyte and in high yield. The crude product could be used for further conversions, such as to pyrimidines without purification. Compared to established synthetic routes neither prior processing of cyanamide was necessary, nor precious transition-metal catalyst were required, nor any reagent waste was produced, and only biocompatible and sustainable solvents were employed for this process, following the requirements ofgreen chemistry.
SIMPLE AMIDINIUM CARBOXYLATES - AN MO TREATMENT OF MOLECULAR GEOMETRY AND ELECTRONIC STRUCTURE
Krechl, Jiri,Boehm, Stanislav,Smrckova, Svatava,Kuthan, Josef
, p. 673 - 683 (2007/10/02)
Carboxylates of amidines (I,II), substituted guanidine (III) and iso(thio)ureas (IV,V) were prepared.Nonempirical quantum chemical treatment of the electronic structure of simple compounds I-V, based on total molecular geometry optimization, their preparation and physicochemical data are reported.Interaction between the two amidinium nitrogens and carboxylate oxygens is mediated by hydrogen bonds and alternation of charge distribution.