138279-15-9

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, bis[(1-oxopropoxy)methyl] ester
• CAS NO: 138279-15-9
• Molecular Formula: C25H30N2O11
• Molecular Weight: 534.52
• Mol File: 138279-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, bis[(1-oxopropoxy)methyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, bis[(1-oxopropoxy)methyl] ester(138279-15-9)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, bis[(1-oxopropoxy)methyl] ester(138279-15-9)

Safety Data

• Hazardous Substances Data: 138279-15-9(Hazardous Substances Data)

Upstream product

• 5402-53-9 chloromethyl propionate 
• 123973-70-6 1,4-dihydro-2,6-dimethyl-1-methoxymethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 

Downstream Products

• 138299-12-4 1-Methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-propionyloxymethyl ester 
• 138299-13-5 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-propionyloxymethyl ester 
• 138693-53-5 (S)-(+)-1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-5-propionyloxymethoxycarbonyl-3-pyridinecarboxylic acid 
• 138279-22-8 1-Methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monopropionyloxymethyl ester 
• 138279-22-8 1-Methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid monopropionyloxymethyl ester 

Relevant articles and documents

Lipase-catalyzed enantioselective hydrolysis of bis(acyloxymethyl) 1,4- dihydro-3,5-pyridinedicarboxylates leading to optically active medicines

Chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates and 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase catalyzed hydrolysis of bis(acyloxymethyl) 1,4-dihydro- 3,5-pyridinedicarboxylate in an H2O/organic solvent system. These chiral dihydropyridines were readily converted into chiral drugs, such as nicardipine, felodipine and PCA 4248.