5402-53-9

Basic information

• Product Name: chloromethyl propanoate
• Synonyms: Chloromethyl propanoate; Chloromethyl propionate
• CAS NO: 5402-53-9
• Molecular Formula: C₄H₇ClO₂
• Molecular Weight: 122.5502
• Mol File: 5402-53-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 105.7°C at 760 mmHg
• Flash Point: 24.4°C
• Density: 1.119g/cm³
• Vapor Pressure: 29.2mmHg at 25°C
• Refractive Index: 1.411
• CAS DataBase Reference: chloromethyl propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: chloromethyl propanoate(5402-53-9)
• EPA Substance Registry System: chloromethyl propanoate(5402-53-9)

Safety Data

• Hazardous Substances Data: 5402-53-9(Hazardous Substances Data)

Usage

General Description

Chloromethyl propanoate is a chemical compound with the molecular formula C5H9ClO2. It is a colorless liquid that is used as an intermediate in the production of various pharmaceuticals and agrochemicals. Its main application is in the synthesis of esters, which are commonly used in the production of fragrances, flavors, and cosmetics. Chloromethyl propanoate is also utilized in the manufacturing of pesticides and herbicides. It is considered to be a hazardous chemical and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system if proper safety precautions are not taken.

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 50-00-0 formaldehyd 
• 79-03-8 propionyl chloride 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 74-97-5 chlorobromomethane 
• 327-62-8 potassium propionate 
• 49715-04-0 chlorosulfuric acid chloromethyl ester 
• 802294-64-0 propionic acid 

Downstream Products

• 47656-35-9 6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid propionyloxymethyl ester 
• 116548-36-8 Propionic acid 2-benzoylamino-acetoxymethyl ester 
• 138279-15-9 bis(propionyloxymethyl) 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 138548-29-5 1,3-bis(propionyloxymethyl)-5-methyl-5-phenylbarbital 
• 138548-31-9 5-(1-cyclohexenyl)-1,3-bis(propionyloxymethyl)-5-methylbarbital 
• 27506-81-6 1,3-bis(propionyloxymethyl)-5-ethyl-5-phenylbarbital 
• 138548-32-0 5-(1-cyclohexenyl)-1,3-bis(propionyloxymethyl)-5-ethylbarbital 
• 138548-30-8 1,3-bis(propionyloxymethyl)-5-phenyl-5-propylbarbital 
• 167221-70-7 Propionoxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1242097-40-0 (Z)-5-phenyl-2-propylpent-2-enyl propionate 
• 1242097-42-2 (Z)-4-methyl-2-(3-phenoxypropyl)hept-2-enyl propionate 
• 1280193-67-0 (Z)-5-phenylpent-2-en-1-yl propionate 
• 1309973-06-5 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(propionyloxymethoxy)phosphonomethoxy]-ethyl}-purine 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C-H Bonds with NaCl/Oxone at Room Temperature

A visible light-induced monochlorination of cyclohexane with sodium chloride (5:1) has been successfully accomplished to afford chlorocyclohexane in excellent yield by using Oxone as the oxidant in H2O/CF3CH2OH at room temperature. Other secondary and primary alkyl sp3 C-H bonds of cycloalkanes and functional branch/linear alkanes can also be chlorinated, respectively, under similar conditions. The selection of a suitable organic solvent is crucial in these efficient radical chlorinations of alkanes in two-phase solutions. It is studied further by the achievement of high chemoselectivity in the chlorination of the benzyl sp3 C-H bond or the aryl sp2 C-H bond of toluene.