1384186-22-4

Basic information

• Product Name: (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide
• Synonyms: (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide
• CAS NO: 1384186-22-4
• Molecular Weight: 575.603
• Mol File: 1384186-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide(1384186-22-4)
• EPA Substance Registry System: (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide(1384186-22-4)

Safety Data

• Hazardous Substances Data: 1384186-22-4(Hazardous Substances Data)

Upstream product

• 244177-70-6 (4S,5R)-3-((2S,3R)-2-isobutyl-3-hydroxypent-4-enoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-on 
• 168540-62-3 (4S,5R)-3-(4-methylpentanoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-on 
• 244177-72-8 (2S,3R)-3-hydroxy-2-isobutylpent-4-enethioic acid S-benzyl ester 
• 58432-84-1 2-(2-iodo-4,5-dimethoxyphenyl)acetonitrile 
• 66384-48-3 2-(2-iodo-4,5-dimethoxyphenyl)ethan-1-amine 
• 244177-76-2 (2S,3R)-3-(tert-butyldimethylsilanyloxy)-2-isobutylpent-4-enoic acid 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 646-07-1 4-Methylpentanoic acid 

Downstream Products

• 1026016-83-0 ((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one) 
• 1228458-05-6 (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one 
• 1384186-23-5 C₅₂H₈₆N₂O₈Si₂ 
• 1228458-10-3 (2R,3S,11bR)-2-hydroxy-3-isobutyl-9,10-dimethoxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-α]isoquinolin-4(11bH)-one 
• 1384186-29-1 C₄₀H₅₈N₂O₈ 
• 1384186-21-3 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(4,5-dimethoxy-2-vinylphenethyl)-2-isobutylpent-4-enamide 

Relevant articles and documents

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine

A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.