1384257-81-1

Basic information

• Product Name: Rivaroxaban Impurity 55
• Synonyms: Rivaroxaban Impurity 55;5-Chloro-N-((2S)-3-chloro-2-hydroxypropyl)thiophene-2-carboxamide
• CAS NO: 1384257-81-1
• Molecular Formula: C8H9Cl2NO2S
• Molecular Weight: 254.13
• Mol File: 1384257-81-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Chloroform, DCM
• CAS DataBase Reference: Rivaroxaban Impurity 55(CAS DataBase Reference)
• NIST Chemistry Reference: Rivaroxaban Impurity 55(1384257-81-1)
• EPA Substance Registry System: Rivaroxaban Impurity 55(1384257-81-1)

Safety Data

• Hazardous Substances Data: 1384257-81-1(Hazardous Substances Data)

Usage

Description

Rivaroxaban Impurity 55, also known as 5-Chloro-N-((2S)-3-chloro-2-hydroxypropyl)thiophene-2-carboxamide, is an intermediate compound in the synthesis of Rivaroxaban (R538000) related compounds. It plays a crucial role in the development of pharmaceuticals, particularly those targeting blood clotting and related conditions.

Uses

Used in Pharmaceutical Industry:
Rivaroxaban Impurity 55 is used as an intermediate compound for the synthesis of Rivaroxaban (R538000) related compounds. It contributes to the development of medications that address blood clotting issues and related health conditions, such as deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Its role in the synthesis process is essential for creating effective and safe pharmaceutical products.

Upstream product

• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 34839-13-9 (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride 
• 1412421-58-9 C₈H₇ClO₄S 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 34839-13-9 (S)-1-amino-3-chloro-2-propanol hydrochloride 

Downstream Products

• 366789-02-8 Rivaroxaban 
• 721401-53-2 5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide 

Relevant articles and documents

Method for preparing rivaroxaban intermediate and method for preparing rivaroxaban from rivaroxaban intermediate

The invention provides a method for preparing a rivaroxaban intermediate shown as a formula (VI) and a method for preparing rivaroxaban. The preparation method of the intermediate has the advantages of simple steps, easily controlled conditions, good selectivity, high yield, few impurities and the like, and green synthesis of rivaroxaban can be realized.

PROCESS FOR THE PREPARATION OF RIVAROXABAN

The present invention provides processes for the preparation of rivaroxaban. The present invention also provides an intermediate for the preparation of rivaroxaban.

PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF

The present invention provides processes for the preparation of rivaroxaban and its intermediates.