34839-13-9

Basic information

• Product Name: (S)-1-Amino-3-chloro-2-propanol hydrochloride
• Synonyms: (S)-1-Amino-3-chloro-2-propanol hydrochloride;(2S)-1-Amino-3-chloro-2-propanol hydrochloride;2-Propanol,1-aMino-3-chloro-, hydrochloride (1:1), (2S)-;(S)-1-AMino-3-chloropropan-2-ol hydrochloride;(2S)-1-amino-3-chloropropan-2-ol hydrochloride (1:1)
• CAS NO: 34839-13-9
• Molecular Formula: C3H9Cl2NO
• Molecular Weight: 146.02
• EINECS: 1312995-182-4
• Mol File: 34839-13-9.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 240.2°Cat760mmHg
• Flash Point: 99.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0067mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Water (Slightly)
• CAS DataBase Reference: (S)-1-Amino-3-chloro-2-propanol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-Amino-3-chloro-2-propanol hydrochloride(34839-13-9)
• EPA Substance Registry System: (S)-1-Amino-3-chloro-2-propanol hydrochloride(34839-13-9)

Safety Data

• Hazardous Substances Data: 34839-13-9(Hazardous Substances Data)

Usage

Description

(S)-1-Amino-3-chloro-2-propanol hydrochloride is an organic compound with the molecular formula C3H8ClNO?HCl. It is a derivative of 3-amino-2-chloropropanol, featuring a hydroxyl group and a chlorine atom in the 3-position, and an amino group in the 1-position. (S)-1-Amino-3-chloro-2-propanol hydrochloride is known for its potential applications in various fields, particularly in biological studies and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
(S)-1-Amino-3-chloro-2-propanol hydrochloride is used as an active pharmaceutical ingredient for the development of male antifertility agents. It is particularly effective when administered orally, as it targets the sperm in the epididymal and vas deferens regions, thereby providing a non-invasive method for male contraception.
Used in Biological Studies:
In the field of biological research, (S)-1-Amino-3-chloro-2-propanol hydrochloride serves as a valuable tool for studying the effects of various compounds on male fertility. It can be used to investigate the mechanisms underlying sperm development, maturation, and function, as well as to identify potential targets for the development of novel contraceptive agents.

InChI:InChI=1/C3H8ClNO.ClH/c4-1-3(6)2-5;/h3,6H,1-2,5H2;1H/t3-;/m1./s1

Upstream product

• 106-89-8 epichlorohydrin 
• 67843-74-7 (S)-epichlorohydrin 
• 100-52-7 benzaldehyde 
• 681225-50-3 (2S)-1-azido-3-chloropropan-2-ol 
• 6937-15-1 (S,E)-1-(benzylideneamino)-3-chloropropan-2-ol 
• 7647-01-0 hydrogenchloride 
• 148857-42-5 2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione 
• 224323-52-8 (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol 
• 19667-37-9 2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione 
• 6937-15-1 3-benzylidenamino-1-chloropropan-2-ol 

Downstream Products

• 53460-78-9 rac-1-acetamido-2-acetoxy-3-chloropropane 
• 415684-05-8 tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate 
• 570390-94-2 tert-butyl-3-chloro-2-hydroxypropylcarbamate 
• 1384257-81-1 N-[(2S)-3-chloro-2-hydroxypropyl]-5-chlorothiophene-2-carboxamide 
• 183905-31-9 N-[(2S)-2-acetoxy-3-chloropropyl]acetamide 

Relevant articles and documents

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

A series of novel oxazolidinone derivatives bearing fluoroalkyl-substituted pyrazole as the C-ring structure were designed, synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most of the target compounds have good antibacterial activity. Especially, compounds 13f, 13i and 13l show excellent activity comparable to linezolid.

Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols

Benzophenone imine was found to be an effective ammonia surrogate for the selective preparation of primary 1,2-amino alcohols from epoxides, including enantiopure epichlorohydrin, in the presence of catalytic Y(OTf)3. High-throughput screening of 48 Lewis acids quickly identified Y(OTf)3 as an effective mediator of the addition reaction under mild conditions. Following acidic hydrolysis, the primary amino alcohol salt is revealed and partitions into the aqueous solution, while the benzophenone byproduct is easily removed by simple extraction with ethyl acetate. These ammonium salts can be directly Boc-protected or further derivatized without isolation to form benzamides and sulfonamides under Schotten-Baumann-type conditions in up to 79% isolated yield over three steps. This methodology has been used to prepare key intermediates for the synthesis of PRMT5 inhibitors with high enantiopurity as well as numerous other amide and sulfonamide derivatives.

OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS

The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosiscomprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or apharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.