224323-52-8

Basic information

• Product Name: (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol
• Synonyms: (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol
• CAS NO: 224323-52-8
• Molecular Weight: 197.664
• Mol File: 224323-52-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol(224323-52-8)
• EPA Substance Registry System: (S)(E,Z)-1-(benzylideneamino)-3-chloropropan-2-ol(224323-52-8)

Safety Data

• Hazardous Substances Data: 224323-52-8(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 100-52-7 benzaldehyde 

Downstream Products

• 115246-65-6 (R)-N-benzoyl-γ-amino-β-hydroxybutyric acid 
• 1414932-73-2 (S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one 
• 1429333-93-6 N-[(R)-2-hydroxy-3-{ 4-(3-oxomorpholin-4-yl)phenylamino}propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-92-5 N-(S)-(1-oxiranylmethyl)-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-91-4 N-[(2S)-3-chloro-2-{(phenyloxycarbonyl)oxy}propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-90-3 5-chloro-N-[{(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl]-N-benzyl-2-thiophene carboxamide 
• 1429333-88-9 N-[(2S)-3-chloro-2-(acetyloxy)propyl]-N-benzyl-5-chlorothiophene-2-carboxamide 
• 1429333-89-0 N-[(2S)-3-chloro-2-hydroxypropyl]-N'-benzyl-5-chlorothiophene-2-carboxamide 
• 198755-87-2 (2S)-1-chloro-3-[(phenylmethyl)amino]-2-propanol 
• 1345879-72-2 (S)(E,Z)-N-benzylidene-1-(oxiran-2-yl)methanamine 
• 1330034-71-3 (S)-(E,Z)-5-((benzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one 
• 34839-13-9 (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride 

Relevant articles and documents

A Process for preparing linezolid and its intermediate

The present invention relates to a manufacturing method of linezolid which is an oxazolidinone-based antibiotic. More specifically, the present invention relates to a novel manufacturing method of linezolid; and to an intermediate compound of linezolid, and the manufacturing method of linezolid uses a novel halomethyl ethanone compound as an intermediate for the manufacture of linezolid, thereby simplifying a manufacturing process and reducing manufacturing costs in comparison with a conventional manufacturing method. The intermediate compound is a novel compound, and is an (S)-1-(5-(halomethyl)-2, 2-dimethyl oxazolidine-3-yl)ethanone compound represented by chemical formula 1. In chemical formula 1, R is one element selected from F, Cl, Br, and I. The manufacturing method of linezolid comprises: a step (A) of performing a reaction process of a compound represented by chemical formula 1 and a compound represented by chemical formula 2 to manufacture a compound represented by chemical formula 3; a step (B) of hydrolyzing the compound represented by chemical formula 3 to obtain a compound represented by chemical formula 4; and a step (C) of performing carbonylation of the compound represented by chemical formula 4.COPYRIGHT KIPO 2016

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

A series of novel oxazolidinone derivatives bearing fluoroalkyl-substituted pyrazole as the C-ring structure were designed, synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most of the target compounds have good antibacterial activity. Especially, compounds 13f, 13i and 13l show excellent activity comparable to linezolid.

PROCESSES FOR PREPARING RIVAROXABAN

Processes and intermediates for preparing rivaroxaban, and analogs and derivatives thereof, and pharmaceutically acceptable salts of each of the foregoing, are described herein.