1384517-64-9

Basic information

• Product Name: 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide
• Synonyms: 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide
• CAS NO: 1384517-64-9
• Molecular Weight: 316.4
• Mol File: 1384517-64-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide(1384517-64-9)
• EPA Substance Registry System: 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide(1384517-64-9)

Safety Data

• Hazardous Substances Data: 1384517-64-9(Hazardous Substances Data)

Upstream product

• 2430-01-5 2-bromo-N,N-diethylacetamide 
• 884504-22-7 3-(4-isopropoxyphenyl)-3-oxopropanenitrile 
• 35826-59-6 methyl 4-isopropoxybenzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 685-91-6 diethylacetamide 

Downstream Products

• 1384517-66-1 2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide 
• 868072-17-7 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide 
• 1262278-66-9 2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide 
• 1384517-65-0 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide 

Relevant articles and documents

[18F] DPA-714 (N, N-diethyl-2-(2-(4-(2-[18]F-fluoroethyoxy)phenyl)-5, 7-dimethylpyrazolo[1, 5-a]pyrimidin-3-yl)aceamide) derivative and preparation and application methods thereof

The invention discloses a [18F] DPA-174 derivative. The [18F] DPA-174 derivative is prepared by modifying the benzene ring structure of or prolonging the carbon chain structure of a [18]F DPA-174 imaging agent. The invention also discloses preparation and application methods of the [18F] DPA-174 derivative. The [18F] DPA-174 derivative is simple in preparation, easy to implement, high in labellingyield and good in repeatability and can help in real time observe and in vivo monitor the status of intracerebral neuroinflammation of an animal model as well as the changes of the major organs and tissues of the animal model; the prepared imaging agents can achieve imaging effects on neuroinflammation; the [18F] DPAF imaging agent can achieve a high signal-to-noise ratio on neuroinflammation lesions to provide possibility for further monitoring and assessing the diagnosis and treatment effects on neuroinflammation..

A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7- dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands

A practical, multigram approach to the 2-(2-(4-alkoxyphenyl)-5,7- dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of ligands targeting the translocator protein (TSPO) is described. This synthetic route offers several improvements over all previously described sequences, including the isolation of intermediates without resort to chromatography. The common precursor to the DPA class of high affinity TSPO ligands, N,N-diethyl-2-(2-(4- hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide, was produced in 40% yield over six steps, and was cleanly alkylated to give multigram quantities of several DPA analogues in 90-96% yield after recrystallization.