868072-17-7

Basic information

• Product Name: 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide
• Synonyms: 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide
• CAS NO: 868072-17-7
• Molecular Weight: 352.436
• Mol File: 868072-17-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide(868072-17-7)
• EPA Substance Registry System: 2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide(868072-17-7)

Safety Data

• Hazardous Substances Data: 868072-17-7(Hazardous Substances Data)

Upstream product

• 386297-97-8 2-[2-(4'-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide 
• 121-98-2 methyl 4-methoxybenzoate 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 386298-14-2 N,N-diethyl-[3-cyano-4-(4-methoxyphenyl)-4-oxo]butanamide 
• 386298-19-7 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide 
• 884504-22-7 3-(4-isopropoxyphenyl)-3-oxopropanenitrile 
• 1384517-65-0 2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide 
• 1384517-66-1 2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide 
• 35826-59-6 methyl 4-isopropoxybenzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 1384517-64-9 3-cyano-N,N-diethyl-4-(4-isopropoxyphenyl)-4-oxobutanamide 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 122488-52-2 ethyl 4-isopropoxybenzoate 

Downstream Products

• 1254174-27-0 2-[5,7-dimethyl-2-(4-(prop-2-yn-1-yloxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide 
• 958233-17-5 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Efficient tritiation of the translocator protein (18kDa) selective ligand DPA-714

DPA-714 (N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide) is a recently discovered fluorinated ligand of the translocator protein 18 kDa (TSPO). Labelled with the short-lived positron emitter fluorine-18, th

Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma

Mitochondria mediate critical cellular processes, including proliferation, apoptosis, and immune responses; as such, their dysfunction is pathogenic in many neurodegenerative disorders and cancers. In glioblastoma, targeted delivery of mitochondria-focuse

Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide

Translocator protein (TSPO) expression is closely related with neuroinflammation and neuronal damage which might cause several central nervous system diseases. Herein, a series of TSPO ligands (11a–c and 13a–d) with a 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamide structure were prepared and evaluated via an in vitro binding assay. Most of the novel ligands exhibited a nano-molar affinity for TSPO, which was better than that of DPA-714. Particularly, 11a exhibited a subnano-molar TSPO binding affinity with suitable lipophilicity for in vivo brain studies. After radiolabeling with fluorine-18, [18F]11a was used for a dynamic positron emission tomography (PET) study in a rat LPS-induced neuroinflammation model; the inflammatory lesion was clearly visualized with a superior target-to-background ratio compared to [18F]DPA-714. An immunohistochemical examination of the dissected brains confirmed that the uptake location of [18F]11a in the PET study was consistent with a positively activated microglia region. This study proved that [18F]11a could be employed as a potential PET tracer for detecting neuroinflammation and could give possibility for diagnosis of other diseases, such as cancers related with TSPO expression.