138495-04-2

Basic information

• Product Name: methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate
• Synonyms: methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate
• CAS NO: 138495-04-2
• Molecular Weight: 333.815
• Mol File: 138495-04-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate(138495-04-2)
• EPA Substance Registry System: methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate(138495-04-2)

Safety Data

• Hazardous Substances Data: 138495-04-2(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1749-03-7 N-(4-chlorobenzylidene)-4-methoxyaniline 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 279687-54-6 5-(4-chlorophenyl)pyrrolidin-2-one 

Relevant articles and documents

Electroreductive coupling of aromatic ketones, aldehydes, and aldimines with α,β-unsaturated esters: Synthesis of 5-aryl substituted γ-butyrolactones and lactams

The electroreductive intermolecular coupling of aromatic ketones and aldehydes with α,β-unsaturated esters in the presence of TMSCl gave the adducts as γ-trimethylsiloxy esters. The detrimethylsilylation of the adducts with TBAF afforded 5-aryl substituted γ-butyrolactones. The electroreductive coupling of N-(4-methoxyphenyl)-1-arylmethaneimines with methyl acrylate in the presence of TMSCl gave the adducts as methyl 4-aryl-4-((4-methoxyphenyl)amino)butanoates. The adducts were transformed to 5-aryl-γ-butyrolactams by cyclization with NaH and subsequent oxidation with CAN. (±)-Norcotinine was prepared from nicotinaldehyde by this method. The electroreductive coupling of aromatic ketones and aldimines with acrylonitrile in the presence of TMSCl gave 4-aryl-4-(trimethylsiloxy)butanenitriles and 4-aryl-4-((4-methoxyphenyl)amino)butanenitriles, respectively.