279687-54-6

Basic information

• Product Name: 5-(4-Chlorophenyl)pyrrolidin-2-one
• Synonyms: 5-(4-Chlorophenyl)pyrrolidin-2-one;5-(4-chlorophenyl)-2-Pyrrolidinone
• CAS NO: 279687-54-6
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.6455
• Mol File: 279687-54-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-Chlorophenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chlorophenyl)pyrrolidin-2-one(279687-54-6)
• EPA Substance Registry System: 5-(4-Chlorophenyl)pyrrolidin-2-one(279687-54-6)

Safety Data

• Hazardous Substances Data: 279687-54-6(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)pyrrolidin-2-one, also known as 4-Cl-α-PVP or 4-chloro-α-pyrrolidinopentiophenone, is a synthetic cathinone and stimulant drug. It is a psychoactive substance that acts as a norepinephrine-dopamine reuptake inhibitor, leading to increased levels of dopamine and norepinephrine in the brain. 5-(4-Chlorophenyl)pyrrolidin-2-one is a derivative of α-PVP, and is known for its potential for abuse and addiction. It has been reported to produce effects such as increased energy, alertness, and euphoria, but can also lead to negative side effects and health risks, including cardiovascular problems, psychosis, and dependence. The use and sale of 5-(4-Chlorophenyl)pyrrolidin-2-one is often regulated and controlled in many countries due to its potential for misuse and harm.

Upstream product

• 53503-49-4 ethyl 4-(4-chlorophenyl)-4-oxobutanoate 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 1749-03-7 N-(4-chlorobenzylidene)-4-methoxyaniline 
• 138495-04-2 methyl 4-(4-chlorophenyl)-4-((4-methoxyphenyl)amino)butanoate 
• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 54654-08-9 4-(4-chlorophenyl)butanoyl chloride 
• 77287-34-4 formamide 

Relevant articles and documents

Highly Robust Iron Catalyst System for Intramolecular C(sp3)?H Amidation Leading to γ-Lactams

Disclosed here is the use of an iron catalyst system for an intramolecular C?H amidation toward γ-lactam synthesis from dioxazolone precursors. (Phthalocyanine)FeIIICl was found to catalyze this cyclization with extremely high turnover numbers of up to 47 000 under mild and aerobic conditions. On the basis of experimental and computational mechanistic studies, the reaction is suggested to proceed by a stepwise radical pathway involving fast hydrogen atom abstraction followed by radical rebound. A plausible origin for the high turnover numbers along with air-compatibility is also rationalized.

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Method for synthesizing lactam derivative without catalyst

The invention discloses a simple synthesis method for a lactam derivative. The method comprises the step that with formamide as an amine source and a hydrogen donor (hydrolyzed to produce formic acid)and keto acid as raw materials, the lactam derivative is easily synthesized through a cycloamination reaction without a solvent or a catalyst. Compared with previous reports, the time required for the reaction is greatly shortened, the selectivity is remarkably improved, the conversion rate of the keto acid derivative is 99%, and the yield of the lactam derivative can reach 70-94%.