138512-74-0

Basic information

• Product Name: 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
• Synonyms: 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
• CAS NO: 138512-74-0
• Molecular Weight: 243.303
• Mol File: 138512-74-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 299.0±33.0 °C(Predicted)
• Density: 1.083±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate(138512-74-0)
• EPA Substance Registry System: 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate(138512-74-0)

Safety Data

• Hazardous Substances Data: 138512-74-0(Hazardous Substances Data)

Usage

General Description

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate is a chemical compound with the molecular formula C13H23NO4. It is a pyrrolidine-derived compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The presence of the tert-butyl and methyl groups in the molecule imparts it with unique chemical and physical properties, making it suitable for various applications. 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate is often used in medicinal chemistry and drug development due to its potential pharmacological activities. It is important in the research and development of new drugs and therapeutic agents. Overall, 1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate is a versatile chemical compound with potential applications in the pharmaceutical and chemical industries.

Upstream product

• 220047-92-7 1-tert-butyl 2-methyl (2S,4R)-4-hydroxymethylpyrrolidine-1,2-dicarboxylate 
• 196394-49-7 (2S,4R)-1-(tert-butyl) 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 220047-71-2 (2S,4R)-2-Benzyloxymethyl-4-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 220047-57-4 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine 
• 220047-73-4 (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-methylpyrrolidine 
• 220047-75-6 tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate 
• 186581-53-3 diazomethane 
• 364750-80-1 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid 
• 328-38-1 (R)-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 123489-10-1 (R)-methyl 2-azido-4-methylpentanoate 

Downstream Products

• 23009-50-9 trans-4-methyl-L-proline 
• 364750-80-1 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid 
• 32968-78-8 (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride 

Relevant articles and documents

NITROGEN CONTAINING BICYCLIC COMPOUNDS

Nitrogen containing bicyclic compounds of Formula (I), pharmaceutical compositions comprising these compounds and their use in treating bacterial infection is disclosed.

N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3)–H Amination of Alkyl Azides

Metal-catalyzed intramolecular C?H amination of alkyl azides constitutes an appealing approach to alicyclic amines; challenges remain in broadening substrate scope, enhancing regioselectivity, and applying the method to natural product synthesis. Herein we report an iron(III) porphyrin bearing axial N-heterocyclic carbene ligands which catalyzes the intramolecular C(sp3)–H amination of a wide variety of alkyl azides under microwave-assisted and thermal conditions, resulting in selective amination of tertiary, benzylic, allylic, secondary, and primary C?H bonds with up to 95 % yield. 14 out of 17 substrates were cyclized selectively at C4 to give pyrrolidines. The regioselectivity at C4 or C5 could be tuned by modifying the reactivity of the C5–H bond. Mechanistic studies revealed a concerted or a fast re-bound mechanism for the amination reaction. The reaction has been applied to the syntheses of tropane, nicotine, cis-octahydroindole, and leelamine derivatives.

HEPATITIS C VIRUS INHIBITORS

This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds