364750-80-1Relevant articles and documents
Stereodivergent and stereoselective synthesis of cis-and trans-4-substituted prolinols
Ando, Junki,Tazawa, Aoi,Ishizawa, Kohei,Tanaka, Minoru,Takamura, Hiroyoshi
, p. 188 - 199 (2019/07/31)
- Stereoselective synthesis of 4-substituted prolinol derivatives has been developed. Thus, Suzuki-Miyaura cross-coupling of vinyl tritiate provided the common synthetic intermediates toward the stereodivergent synthesis of cis- and ira?s-4-substituted prolinols. These two kinds of target compounds were obtained by diastereoselective hydrogenation of the coupling products with Pd/C and Crabtree catalyst, respectively. In addition, the obtained 4-substituted prolinol was transformed to the corresponding proline derivative via oxidation in one step.
CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
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Page/Page column 34, (2014/03/21)
This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.
Highly efficient syntheses of azetidines, pyrrolidines, and indolines via palladium catalyzed intramolecular amination of C(sp3)-H and C(sp2)-H bonds at γ and δ positions
He, Gang,Zhao, Yingsheng,Zhang, Shuyu,Lu, Chengxi,Chen, Gong
supporting information; experimental part, p. 3 - 6 (2012/02/16)
Efficient methods have been developed to synthesize azetidine, pyrrolidine, and indoline compounds via palladium-catalyzed intramolecular amination of C-H bonds at the γ and δ positions of picolinamide (PA) protected amine substrates. These methods feature relatively a low catalyst loading, use of inexpensive reagents, and convenient operating conditions. Their selectivities are predictable. These methods highlight the use of unactivated C-H bond, especially the C(sp3)-H bond of methyl groups, as functional groups in organic synthesis.