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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(2S,3S)-TRANS-3-METHYLOXIRANE-2-METHYL4-NITROBENZOATE

Cas:364750-80-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 364750-80-1 with competitive price

Cas:364750-80-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acidCAS364750-80-1

Cas:364750-80-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

(2S,4R)-N-BoC-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(2S,4R)-N-BOC-4-METHYLPYRROLIDINE-2-CARBOXYLIC ACIDCASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(2S,4R)-N-BOC-4-METHYLPYRROLIDINE-2-CARBOXYLIC ACIDCAS

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

home-produced Application:medicine

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(2S,4R)-1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

1,2-Pyrrolidinedicarboxylicacid, 4-methyl-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Cas:364750-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ENAO Chemical Co, Limited

For quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,

(2S,4R)-1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

nanjing bam biomedical technology co.,ltd

It is composed of professionals with senior industry background and rich market experience. More than 90% of the personnel have chemistry, chemical, pharmaceutical or related professional knowledge. They are all rigorously trained and evaluated, and

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Reply quotation within 2 hours.Guarantee the time of delivery. Update the progress of customization Weekly.High purity& High product customization success rate.Inquiries for other compounds are acceptable. Storage:refrigeration Package:1g,5g,10g,100g

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (2S,4R)-1-[(tert-Butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid, CAS:364750-8

(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Cyanochem Co; Ltd.

superior product, rigorous quality test, GMP management and auditable plant, stable supply in industry park, advantage in R&D CMO CROAppearance:white or off-white powder Storage:storage in norm temperature and against damp Package:Aluminum drum or fo

(2S,4R)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

coolpharm Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

(2S,4R)-N-BOC-4-METHYLPYRROLIDINE-2-CARBOXYLIC ACID

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Jingshi Pharmaceutical Technology Co., Ltd.

We promise quality; We deliver goods timely; We test product purity before delivery;We quote price reasonabl;We guarantee after sale service.Appearance:White or off-white crystalline powder Storage:cool and dry area,avoiding light Package:1g/5g/10g/2

(2S,4R)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Drug Miracle Ltd

We are a legitimate company that deals with research chemicals and pharmaceutical products of both powder, crystal and pills or tablets and our pro… Package:Discreet Packaging Port:Chocago

(2S,4R)-N-Boc-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:100 Gram

FOB Price: $360.0 / 2500.0

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Cas:364750-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate
220047-75-6

tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In water; acetonitrile at 20℃; for 15h;100%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; NaH2PO4 buffer; sodium hypochlorite In water; acetonitrile at 45℃; for 24h; pH=6.6;84%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; potassium bromide In acetone at 0℃; for 2h;
C11H19NO4

C11H19NO4

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: C11H19NO4 With trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran; toluene at -30 - 23℃; for 0.666667h; Inert atmosphere;
Stage #2: With methanesulfonyl chloride; triethylamine In tetrahydrofuran at -78 - 23℃; for 1h; Inert atmosphere; Further stages;
44%
L-leucine
61-90-5

L-leucine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

A

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline
364750-81-2

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline

B

(2S)-2-(ter-butoxycarbonylamino)-4,4-dimethyl-4-butanolide

(2S)-2-(ter-butoxycarbonylamino)-4,4-dimethyl-4-butanolide

C

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multistep reaction;A n/a
B 12%
C n/a
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h
2.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C
3.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling
4.1: 78 percent / TEA; DMAP / CH2Cl2
5.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
6.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
6.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
7.1: Raney-Ni; hydrogen / methanol / Heating
8.1: TBAF / tetrahydrofuran
9.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: lithium borohydride / tetrahydrofuran / 20 °C
View Scheme
tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate
61478-26-0

tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 78 percent / TEA; DMAP / CH2Cl2
2.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
3.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
4.1: Raney-Ni; hydrogen / methanol / Heating
5.1: TBAF / tetrahydrofuran
6.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
13726-69-7

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C
2.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling
3.1: 78 percent / TEA; DMAP / CH2Cl2
4.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
5.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
5.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
6.1: Raney-Ni; hydrogen / methanol / Heating
7.1: TBAF / tetrahydrofuran
8.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(2S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
125653-58-9

(2S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
2.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
3.1: Raney-Ni; hydrogen / methanol / Heating
4.1: TBAF / tetrahydrofuran
5.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(2S,4R)-4-Hydroxy-2-isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-4-Hydroxy-2-isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling
2.1: 78 percent / TEA; DMAP / CH2Cl2
3.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
4.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
5.1: Raney-Ni; hydrogen / methanol / Heating
6.1: TBAF / tetrahydrofuran
7.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h
2.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C
3.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling
4.1: 78 percent / TEA; DMAP / CH2Cl2
5.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C
6.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
6.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
7.1: Raney-Ni; hydrogen / methanol / Heating
8.1: TBAF / tetrahydrofuran
9.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(S)-tert-butyl 2-(hydroxymethyl)-4-methylenepyrrolidine-1-carboxylate
181295-78-3

(S)-tert-butyl 2-(hydroxymethyl)-4-methylenepyrrolidine-1-carboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / Ir(COD)PyPCy3PF6; hydrogen / CH2Cl2 / 18 h / 20 °C / 760 Torr
2: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

2-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TBAF / tetrahydrofuran
2: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(S)-tert-butyl 2-((tert-butyldimethylsilyloxy)methyl)-4-oxopyrrolidine-1-carboxylate
220993-22-6

(S)-tert-butyl 2-((tert-butyldimethylsilyloxy)methyl)-4-oxopyrrolidine-1-carboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C
1.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
2.1: Raney-Ni; hydrogen / methanol / Heating
3.1: TBAF / tetrahydrofuran
4.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
Multi-step reaction with 5 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / 1,4-dioxane; water / 1 h / 100 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C
4: hydrogen; Crabtree's catalyst / dichloromethane / 12 h / 20 °C
5: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 15 h / 20 °C
View Scheme
(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylenepyrrolidine
540501-23-3

(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylenepyrrolidine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / TBAF / tetrahydrofuran / 6 h / 20 °C
2: 90 percent / Ir(COD)PyPCy3PF6; hydrogen / CH2Cl2 / 18 h / 20 °C / 760 Torr
3: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-(phenylthio)methylenepyrrolidine
540501-65-3

(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-(phenylthio)methylenepyrrolidine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Raney-Ni; hydrogen / methanol / Heating
2: TBAF / tetrahydrofuran
3: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6
View Scheme
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-methylpyrrolidine
220047-73-4

(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-methylpyrrolidine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
2: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine
220047-57-4

((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 63 percent / K2CO3 / dimethylformamide / 48 h / 80 °C
2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature
3: 85 percent / pyridine / 24 h / 0 °C
4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
6: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
7: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
8: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
9: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
10: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
11: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
Multi-step reaction with 11 steps
1: 90 percent / NaBH3CN / 1,2-dichloro-ethane / 6 h / Ambient temperature
2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature
3: 85 percent / pyridine / 24 h / 0 °C
4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
6: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
7: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
8: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
9: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
10: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
11: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
(2S,4R)-2-Benzyloxymethyl-4-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
220047-71-2

(2S,4R)-2-Benzyloxymethyl-4-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
2: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
3: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine
212266-65-4

(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
2: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
3: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
4: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol
220047-66-5

((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
2: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
3: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
4: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
5: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
6: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-oxiranylmethyl-amine

((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-oxiranylmethyl-amine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
2: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
3: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
4: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
5: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
6: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
7: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
(2R,3S,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
220047-69-8

(2R,3S,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
2: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
3: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
4: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
5: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol
212266-69-8

(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 85 percent / pyridine / 24 h / 0 °C
2: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
3: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
4: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
5: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
6: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
7: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
8: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
9: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine
212266-68-7

((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature
2: 85 percent / pyridine / 24 h / 0 °C
3: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
4: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
5: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
6: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
7: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
8: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
9: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
10: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
Toluene-4-sulfonic acid (S)-3-[((R)-2-benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-2-hydroxy-propyl ester
212266-70-1

Toluene-4-sulfonic acid (S)-3-[((R)-2-benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-2-hydroxy-propyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
2: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C
3: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature
4: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C
5: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h
6: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C
7: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature
8: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C
View Scheme
4-methyl-pyrrolidine-2-carboxylic acid methyl ester

4-methyl-pyrrolidine-2-carboxylic acid methyl ester

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C
2: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr
3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C
View Scheme
C20H34N2O4Si
1353864-31-9

C20H34N2O4Si

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid / toluene / 24 h / 110 °C / Inert atmosphere
2: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C
3: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C
4: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr
5: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C
View Scheme
C20H32N2O4Si
1353864-33-1

C20H32N2O4Si

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C
2: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C
3: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr
4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C
View Scheme
C15H19NO4
1353864-35-3

C15H19NO4

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr
2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C
View Scheme
methyl (L)-leucinate hydrochloride
7517-19-3

methyl (L)-leucinate hydrochloride

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2: [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid / toluene / 24 h / 110 °C / Inert atmosphere
3: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C
4: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C
5: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr
6: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C
View Scheme
1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
138512-74-0

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 20℃; for 14h;
With water; lithium hydroxide In ethanol at 0 - 20℃; for 5h;
With lithium borohydride In tetrahydrofuran at 20℃;92 g
2-oxo-2-phenylethyl ((benzyloxy)carbonyl)-L-allothreoninate
1542206-68-7

2-oxo-2-phenylethyl ((benzyloxy)carbonyl)-L-allothreoninate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

2-((2S,3S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2-oxo-2-phenylethoxy)butan-2-yl) 1-(tert-butyl) (2S,4S)-4-methylpyrrolidine-1,2-dicarboxylate

2-((2S,3S)-3-(((benzyloxy)carbonyl)amino)-4-oxo-4-(2-oxo-2-phenylethoxy)butan-2-yl) 1-(tert-butyl) (2S,4S)-4-methylpyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;83%
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate
220047-75-6

tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 30℃; for 2h;83%
methanol
67-56-1

methanol

<2-(13)C>acetyl chloride
14770-40-2

<2-(13)C>acetyl chloride

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

N-(2-13CH3-acetyl)-(2S,4R)-4-methylproline methyl ester

N-(2-13CH3-acetyl)-(2S,4R)-4-methylproline methyl ester

Conditions
ConditionsYield
Stage #1: methanol; (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid With acetyl chloride at 0 - 20℃;
Stage #2: <2-(13)C>acetyl chloride With dmap In dichloromethane at 20℃; for 24h;
77%
4-Bromo-benzene-1,2-diamine
1575-37-7

4-Bromo-benzene-1,2-diamine

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

C17H22BrN3O2

C17H22BrN3O2

Conditions
ConditionsYield
Stage #1: (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: 4-Bromo-benzene-1,2-diamine In tetrahydrofuran at 20℃; for 2h;
72%
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
138512-74-0

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
In diethyl ether Yield given;
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

trans-4-methyl-L-proline
23009-50-9

trans-4-methyl-L-proline

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 1.5h;
Multi-step reaction with 2 steps
1: diethyl ether
2: 1.) aq. HCl, 2.) propylene oxide / 1.) 100 deg C, 3 h, 2.) EtOH, heating
View Scheme
methanol
67-56-1

methanol

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

(2S,4R)-4-Methyl-pyrrolidine-2-carboxylic acid methyl ester; hydrochloride

(2S,4R)-4-Methyl-pyrrolidine-2-carboxylic acid methyl ester; hydrochloride

Conditions
ConditionsYield
With acetyl chloride at 0 - 20℃; for 6h;
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

trans-4-methyl-L-proline hydrochloride

trans-4-methyl-L-proline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 1.5h;
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine
901139-04-6

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aq. HCl / dioxane / 1.5 h
2: 1.11 g / aq. NaHCO3 / dioxane / 27 h
3: 442 mg / PyBroP; DIEA / CH2Cl2 / 36 h / 20 °C
4: 84 percent / H2 / Pd/C / methanol / 5 h
View Scheme
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester
901139-69-3

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aq. HCl / dioxane / 1.5 h
2: 1.11 g / aq. NaHCO3 / dioxane / 27 h
3: 520 mg / DIEA; PyBroP / CH2Cl2 / 40 h / 20 °C
4: 66 percent / hydrogen / Pd/C / methanol / 2.5 h
View Scheme
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine benzyl ester
901138-97-4

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. HCl / dioxane / 1.5 h
2: 1.11 g / aq. NaHCO3 / dioxane / 27 h
3: 442 mg / PyBroP; DIEA / CH2Cl2 / 36 h / 20 °C
View Scheme
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester
901139-63-7

N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. HCl / dioxane / 1.5 h
2: 1.11 g / aq. NaHCO3 / dioxane / 27 h
3: 520 mg / DIEA; PyBroP / CH2Cl2 / 40 h / 20 °C
View Scheme
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
364750-80-1

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-methylpyrrolidine-2-carboxylic acid
333777-34-7

(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-methylpyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl / dioxane / 1.5 h
2: 1.11 g / aq. NaHCO3 / dioxane / 27 h
View Scheme

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