Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:364750-80-1
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:364750-80-1
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:364750-80-1
Min.Order:1 Kilogram
FOB Price: $10.0 / 20.0
Type:Trading Company
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:364750-80-1
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:364750-80-1
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:364750-80-1
Min.Order:100 Gram
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Type:Other
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:364750-80-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:364750-80-1
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryShanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service
Cas:364750-80-1
Min.Order:0
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inquiryhight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents
Cas:364750-80-1
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inquiryWe are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a
Cas:364750-80-1
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Type:Trading Company
inquiry(2S,4R)-N-BOC-4-METHYLPYRROLIDINE-2-CARBOXYLIC ACIDCASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Cas:364750-80-1
Min.Order:0
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Type:Other
inquiryhome-produced Application:medicine
Cas:364750-80-1
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:364750-80-1
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Cas:364750-80-1
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:364750-80-1
Min.Order:10 Milligram
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Type:Lab/Research institutions
inquiryChangzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
Cas:364750-80-1
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryFor quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,
Cas:364750-80-1
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inquiryIt is composed of professionals with senior industry background and rich market experience. More than 90% of the personnel have chemistry, chemical, pharmaceutical or related professional knowledge. They are all rigorously trained and evaluated, and
Cas:364750-80-1
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inquiryHigh quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS
Cas:364750-80-1
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Type:Lab/Research institutions
inquiry1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi
Cas:364750-80-1
Min.Order:0
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Type:Other
inquiryReply quotation within 2 hours.Guarantee the time of delivery. Update the progress of customization Weekly.High purity& High product customization success rate.Inquiries for other compounds are acceptable. Storage:refrigeration Package:1g,5g,10g,100g
Cas:364750-80-1
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Type:Lab/Research institutions
inquiryFINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (2S,4R)-1-[(tert-Butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid, CAS:364750-8
Cas:364750-80-1
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Type:Trading Company
inquirysuperior product, rigorous quality test, GMP management and auditable plant, stable supply in industry park, advantage in R&D CMO CROAppearance:white or off-white powder Storage:storage in norm temperature and against damp Package:Aluminum drum or fo
Cas:364750-80-1
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Type:Lab/Research institutions
inquiryKnown for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar
Cas:364750-80-1
Min.Order:0
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Type:Other
inquiryDebyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen
Cas:364750-80-1
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Type:Lab/Research institutions
inquiryWe promise quality; We deliver goods timely; We test product purity before delivery;We quote price reasonabl;We guarantee after sale service.Appearance:White or off-white crystalline powder Storage:cool and dry area,avoiding light Package:1g/5g/10g/2
Cas:364750-80-1
Min.Order:0
Negotiable
Type:Trading Company
inquiryWe are a legitimate company that deals with research chemicals and pharmaceutical products of both powder, crystal and pills or tablets and our pro… Package:Discreet Packaging Port:Chocago
Cas:364750-80-1
Min.Order:100 Gram
FOB Price: $360.0 / 2500.0
Type:Trading Company
inquiryhigh purity Application:Drug intermediates Materials intermediates and active molecules
Cas:364750-80-1
Min.Order:0
Negotiable
Type:Trading Company
inquirytert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In water; acetonitrile at 20℃; for 15h; | 100% |
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; NaH2PO4 buffer; sodium hypochlorite In water; acetonitrile at 45℃; for 24h; pH=6.6; | 84% |
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; potassium bromide In acetone at 0℃; for 2h; |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: C11H19NO4 With trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran; toluene at -30 - 23℃; for 0.666667h; Inert atmosphere; Stage #2: With methanesulfonyl chloride; triethylamine In tetrahydrofuran at -78 - 23℃; for 1h; Inert atmosphere; Further stages; | 44% |
L-leucine
di-tert-butyl dicarbonate
A
N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline
C
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multistep reaction; | A n/a B 12% C n/a |
di-tert-butyl dicarbonate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h 2.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C 3.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling 4.1: 78 percent / TEA; DMAP / CH2Cl2 5.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 6.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 6.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 7.1: Raney-Ni; hydrogen / methanol / Heating 8.1: TBAF / tetrahydrofuran 9.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: lithium borohydride / tetrahydrofuran / 20 °C View Scheme |
tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 78 percent / TEA; DMAP / CH2Cl2 2.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 4.1: Raney-Ni; hydrogen / methanol / Heating 5.1: TBAF / tetrahydrofuran 6.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C 2.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling 3.1: 78 percent / TEA; DMAP / CH2Cl2 4.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 5.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 5.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 6.1: Raney-Ni; hydrogen / methanol / Heating 7.1: TBAF / tetrahydrofuran 8.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(2S,4R)-2-(tert-butyldimethylsilanyloxymethyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 2.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 3.1: Raney-Ni; hydrogen / methanol / Heating 4.1: TBAF / tetrahydrofuran 5.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling 2.1: 78 percent / TEA; DMAP / CH2Cl2 3.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 4.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 5.1: Raney-Ni; hydrogen / methanol / Heating 6.1: TBAF / tetrahydrofuran 7.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
4R-4-hydroxyproline
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h 2.1: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C 3.1: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling 4.1: 78 percent / TEA; DMAP / CH2Cl2 5.1: 88 percent / trichloroisocyanuric acid; TEMPO / CH2Cl2 / 1 h / 0 °C 6.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 6.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 7.1: Raney-Ni; hydrogen / methanol / Heating 8.1: TBAF / tetrahydrofuran 9.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(S)-tert-butyl 2-(hydroxymethyl)-4-methylenepyrrolidine-1-carboxylate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / Ir(COD)PyPCy3PF6; hydrogen / CH2Cl2 / 18 h / 20 °C / 760 Torr 2: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TBAF / tetrahydrofuran 2: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(S)-tert-butyl 2-((tert-butyldimethylsilyloxy)methyl)-4-oxopyrrolidine-1-carboxylate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 1.2: 73 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C 2.1: Raney-Ni; hydrogen / methanol / Heating 3.1: TBAF / tetrahydrofuran 4.1: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme | |
Multi-step reaction with 5 steps 1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / 1,4-dioxane; water / 1 h / 100 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C 4: hydrogen; Crabtree's catalyst / dichloromethane / 12 h / 20 °C 5: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 15 h / 20 °C View Scheme |
(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylenepyrrolidine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / TBAF / tetrahydrofuran / 6 h / 20 °C 2: 90 percent / Ir(COD)PyPCy3PF6; hydrogen / CH2Cl2 / 18 h / 20 °C / 760 Torr 3: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(S)-2-tert-butyldimethylsilyloxymethyl-N-tert-butyloxycarbonyl-4-(phenylthio)methylenepyrrolidine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Raney-Ni; hydrogen / methanol / Heating 2: TBAF / tetrahydrofuran 3: 84 percent / NaClO2; TEMPO; aqueous NaH2PO4 buffer / NaClO / H2O; acetonitrile / 24 h / 45 °C / pH 6.6 View Scheme |
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-methylpyrrolidine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 2: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 63 percent / K2CO3 / dimethylformamide / 48 h / 80 °C 2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / pyridine / 24 h / 0 °C 4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 6: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 7: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 8: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 9: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 10: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 11: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme | |
Multi-step reaction with 11 steps 1: 90 percent / NaBH3CN / 1,2-dichloro-ethane / 6 h / Ambient temperature 2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / pyridine / 24 h / 0 °C 4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 6: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 7: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 8: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 9: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 10: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 11: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(2S,4R)-2-Benzyloxymethyl-4-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 2: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 3: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 2: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 3: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 4: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 2: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 3: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 4: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 5: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 6: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 2: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 3: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 4: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 5: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 6: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 7: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(2R,3S,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 2: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 3: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 4: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 5: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 85 percent / pyridine / 24 h / 0 °C 2: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 3: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 4: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 5: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 6: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 7: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 8: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 9: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 2: 85 percent / pyridine / 24 h / 0 °C 3: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 4: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 5: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 6: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 7: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 8: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 9: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 10: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
Toluene-4-sulfonic acid (S)-3-[((R)-2-benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-2-hydroxy-propyl ester
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 2: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 3: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 4: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 5: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 6: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 7: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 8: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr 3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C View Scheme |
C20H34N2O4Si
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid / toluene / 24 h / 110 °C / Inert atmosphere 2: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C 3: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C 4: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr 5: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C View Scheme |
C20H32N2O4Si
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C 2: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C 3: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr 4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C View Scheme |
C15H19NO4
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr 2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C View Scheme |
methyl (L)-leucinate hydrochloride
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2: [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid / toluene / 24 h / 110 °C / Inert atmosphere 3: hydrogenchloride; water / 1,4-dioxane / 24 h / 20 °C 4: sodium hydrogencarbonate / 1,4-dioxane / 3 h / 20 °C 5: palladium on activated charcoal; hydrogen / ethyl acetate / 14 h / 20 °C / 760.05 Torr 6: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 14 h / 20 °C View Scheme |
1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 20℃; for 14h; | |
With water; lithium hydroxide In ethanol at 0 - 20℃; for 5h; | |
With lithium borohydride In tetrahydrofuran at 20℃; | 92 g |
2-oxo-2-phenylethyl ((benzyloxy)carbonyl)-L-allothreoninate
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; | 83% |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
tert-butyl (2S,4R)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at 0 - 30℃; for 2h; | 83% |
methanol
<2-(13)C>acetyl chloride
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: methanol; (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid With acetyl chloride at 0 - 20℃; Stage #2: <2-(13)C>acetyl chloride With dmap In dichloromethane at 20℃; for 24h; | 77% |
4-Bromo-benzene-1,2-diamine
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: (2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: 4-Bromo-benzene-1,2-diamine In tetrahydrofuran at 20℃; for 2h; | 72% |
diazomethane
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate
Conditions | Yield |
---|---|
In diethyl ether Yield given; |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
trans-4-methyl-L-proline
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 1.5h; | |
Multi-step reaction with 2 steps 1: diethyl ether 2: 1.) aq. HCl, 2.) propylene oxide / 1.) 100 deg C, 3 h, 2.) EtOH, heating View Scheme |
methanol
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With acetyl chloride at 0 - 20℃; for 6h; |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 1.5h; |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aq. HCl / dioxane / 1.5 h 2: 1.11 g / aq. NaHCO3 / dioxane / 27 h 3: 442 mg / PyBroP; DIEA / CH2Cl2 / 36 h / 20 °C 4: 84 percent / H2 / Pd/C / methanol / 5 h View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aq. HCl / dioxane / 1.5 h 2: 1.11 g / aq. NaHCO3 / dioxane / 27 h 3: 520 mg / DIEA; PyBroP / CH2Cl2 / 40 h / 20 °C 4: 66 percent / hydrogen / Pd/C / methanol / 2.5 h View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S)-prolyl-glycine benzyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aq. HCl / dioxane / 1.5 h 2: 1.11 g / aq. NaHCO3 / dioxane / 27 h 3: 442 mg / PyBroP; DIEA / CH2Cl2 / 36 h / 20 °C View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
N-9-fuorenylmethoxycarbonyl-(2S,4R)-4-methylprolyl-(2S,4S)-4-methylprolyl-glycine benzyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aq. HCl / dioxane / 1.5 h 2: 1.11 g / aq. NaHCO3 / dioxane / 27 h 3: 520 mg / DIEA; PyBroP / CH2Cl2 / 40 h / 20 °C View Scheme |
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-methylpyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl / dioxane / 1.5 h 2: 1.11 g / aq. NaHCO3 / dioxane / 27 h View Scheme |
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