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138596-87-9

138596-87-9

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  • 1-Pyrrolidinecarboxylic acid, 2-[[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]methyl]-, 1,1-dimethylethyl ester, (S)-

    Cas No: 138596-87-9

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138596-87-9 Usage

Molecular weight

381.55 g/mol

Structure

A pyrrolidine ring with a carboxylic acid group (-COOH) attached to the 1-position, and a 1,3-dithian-2-ylmethyl ester group attached to the 2-position. The ester group is further substituted with two methoxy groups (-OCH3) on a phenyl ring.

Stereochemistry

The compound has a stereocenter at the 2-position, and the S enantiomer is the active form.

Biological activity

S-Rolipram acts as a selective inhibitor of phosphodiesterase-4 (PDE4), an enzyme involved in the regulation of inflammation and immune responses.

Therapeutic applications

S-Rolipram has potential therapeutic applications in conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other chronic inflammatory conditions.

Neuroprotective and antidepressant effects

S-Rolipram has been studied for its potential to protect neurons from damage and to have antidepressant effects.

Check Digit Verification of cas no

The CAS Registry Mumber 138596-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,5,9 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 138596-87:
(8*1)+(7*3)+(6*8)+(5*5)+(4*9)+(3*6)+(2*8)+(1*7)=179
179 % 10 = 9
So 138596-87-9 is a valid CAS Registry Number.

138596-87-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2''S)-2-(3',4'-Dimethoxyphenyl)-2-(N-t-butoxycarbonyl-2''-methylenepyrrolidine)-1,3-dithiane

1.2 Other means of identification

Product number -
Other names (S)-2-[2-(3,4-Dimethoxy-phenyl)-[1,3]dithian-2-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138596-87-9 SDS

138596-87-9Relevant articles and documents

A total synthesis of (-)-ruspolinone

Jones,Woo

, p. 7179 - 7184 (1991)

A synthesis of the pyrrolidine alkaloid (-)-ruspolinone (1) from (2S)-proline in 7 steps and 26% overall yield is presented which assigns the (2S) configuration to (-)-(1). The compound obtained by this route has [α](D)-29.73° compared to a value of zero for the material isolated from the plant suggesting racemisation had occurred during isolation.

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