13909-16-5 Usage
Description
1-(2-chloroethyl)-3-(2,3-dihydro-1H-inden-2-yl)-1-nitrosourea, commonly known as lomustine, is a chemotherapeutic agent derived from the nitrosourea class. It is characterized by its ability to inhibit DNA and RNA synthesis in cancer cells, leading to cell death. Lomustine is notable for its capacity to cross the blood-brain barrier, which makes it a valuable compound in the treatment of brain tumors.
Uses
Used in Oncology:
Lomustine is used as an anticancer agent for the treatment of various malignancies, including brain tumors, melanoma, and Hodgkin's lymphoma. Its effectiveness in treating brain tumors is particularly significant due to its ability to cross the blood-brain barrier. It targets cancer cells by disrupting their nucleic acid synthesis, which is crucial for their proliferation and survival.
However, the use of lomustine must be carefully managed due to its potential to cause serious side effects such as bone marrow suppression, liver toxicity, and pulmonary fibrosis. As a result, it should be administered under the supervision of a healthcare professional.
Ongoing research into lomustine's mechanisms of action and potential applications in different types of cancer aims to enhance our understanding of this compound and improve its therapeutic utility.
Used in Pharmaceutical Research:
Lomustine is also utilized in pharmaceutical research to explore new avenues for cancer treatment. Its unique properties and mechanisms of action make it a subject of interest for scientists seeking to develop novel therapeutic strategies against cancer. The investigation into its potential synergistic effects with other chemotherapeutic agents and its role in targeted cancer therapies is an active area of study.
Check Digit Verification of cas no
The CAS Registry Mumber 13909-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13909-16:
(7*1)+(6*3)+(5*9)+(4*0)+(3*9)+(2*1)+(1*6)=105
105 % 10 = 5
So 13909-16-5 is a valid CAS Registry Number.
