2975-41-9

Basic information

• Product Name: Indan-2-amine
• Synonyms: 2,3-Dihydro-1H-inden-2-ylamine;AKOS BC-0645;2-AMINOINDAN;2-AMINOINDANE;2-INDANAMINE;INDAN-2-AMINE;INDAN-2-YLAMINE;AURORA KA-7507
• CAS NO: 2975-41-9
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 133.19034
• EINECS: 221-021-3
• Product Categories: Amines;Fused Ring Systems;C9 to C10;Nitrogen Compounds;Research chemical;2-Aminoindane (2-AI) ada@tuskwei.com sky;18031153937@189.cn
• Mol File: 2975-41-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 33-34 °C
• Boiling Point: 103-105
• Flash Point: 212 °F
• Appearance: /
• Density: 1.024 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.561(lit.)
• PKA: 9.21±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: Indan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: Indan-2-amine(2975-41-9)
• EPA Substance Registry System: Indan-2-amine(2975-41-9)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• RIDADR: UN 2735 8/PG III
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 2975-41-9(Hazardous Substances Data)

Usage

Description

Indan-2-amine, also known as 2-Aminoindan or 2-Aminoindane, is an analog of amphetamine that exhibits potential bronchodilator and analgesic effects. It is characterized by the presence of an intramolecular N-H···Π hydrogen bond, which influences its conformational properties.

Uses

Used in Pharmaceutical Industry:
Indan-2-amine is used as an analgesic with sympathomimetic activity for its ability to provide pain relief and stimulate certain aspects of the sympathetic nervous system. It is particularly useful in managing various types of pain and has potential applications in the treatment of conditions that require both pain relief and stimulation of the sympathetic nervous system.
Used in Enzyme Inhibition:
Indan-2-amine is used as an inhibitor of norepinephrine methyltransferase, an enzyme involved in the metabolism of neurotransmitters. By inhibiting this enzyme, Indan-2-amine can potentially influence the levels of neurotransmitters in the body, which may have therapeutic implications for certain conditions.

InChI:InChI=1/C9H11N/c10-9-5-7-3-1-2-4-8(7)6-9/h1-4,9H,5-6,10H2

Upstream product

• 189242-48-6 2-amino-3H-indene-1-carbonitrile 
• 26536-31-2 indano<1,2-b>aziridine 
• 3349-63-1 indan-2-one oxime 
• 13943-70-9 2-nitro-2,3-dihydro-1H-inden-1-one 
• 64-17-5 ethanol 
• 613-73-0 1,2-phenylenediacetonitrile 
• 7601-90-3 perchloric acid 
• 15028-10-1 indan-1,2-dione-2-oxime 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 24446-27-3 indan-2-yl-carbamic acid ethyl ester 
• 251980-47-9 2-indanone O-(tert-butyldimethylsilyl)oxime 
• 95-13-6 1-indene 
• 2338-18-3 2-aminoindane hydrochloride 

Downstream Products

• 13908-31-1 1-(2-chloroethyl)-3-(2,3-dihydro-1H-inden-2-yl)urea 
• 133795-82-1 N-(3-phenylpropyl)-2-aminoindan 
• 31952-21-3 2-(2,3-dihydro-1H-inden-2-yl)-1H-isoindole-1,3(2H)-dione 
• 83402-63-5 tert-butyl N-(2,3-dihydro-1H-inden-2-yl)glycinate 
• 74814-29-2 Boc-Tyr(OH)-D-Ala-Gly-2-aminoindan 
• 193756-44-4 N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide 
• 7710-36-3 2-chloro-4,6-di(piperidinyl)-1,3,5-triazine 
• 247587-14-0 2-chloro-4-(N-piperidinyl)-6-(2-aminoindanyl)-1,3,5-triazine 
• 370861-62-4 (+/-)-5-nitro-2-aminoindan hydrogen sulfate salt 
• 73536-83-1 5-chloro-2,3-dihydro-1H-inden-2-ylamine 
• 862388-15-6 ((1S)-1-benzyl-3-(2-indanylamino)-2-hydroxy-3-oxopropyl)carbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

Synthesis of 2-indanyl urea derivatives

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Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Novel method for synthesizing 2-amine indene

The invention provides a novel method for synthesizing 2-amine indene. The novel method includes carrying out nucleophilic substitution reaction on bisbenzene and ethyl cyanoacetate and carrying out decarboxylation procedures to obtain compounds 15; carrying out hydrolysis to obtain compounds 16; ultimately carrying out Hofmann degradation reaction to obtain the 2-amine indene which is a target product. The bisbenzene is a chemical material and is used as a main raw material for the 2-amine indene. Compared with the prior art, the novel method has the advantages that the novel method is shortin reaction path and suitable for industrial large-scale production, raw materials are low in cost and are easily available, reaction conditions are mild, the productivity can be obviously improved, and the production cycle can be obviously shortened.