7710-36-3

Basic information

• Product Name: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine
• Synonyms: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine
• CAS NO: 7710-36-3
• Molecular Formula: C₁₃H₂₀ClN₅
• Molecular Weight: 281.78
• Mol File: 7710-36-3.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 465.4°C at 760 mmHg
• Flash Point: 235.3°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 7.69E-09mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(7710-36-3)
• EPA Substance Registry System: 2-Chloro-4,6-di(1-piperidinyl)-1,3,5-triazine(7710-36-3)

Safety Data

• Hazardous Substances Data: 7710-36-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H20ClN5/c14-11-15-12(18-7-3-1-4-8-18)17-13(16-11)19-9-5-2-6-10-19/h1-10H2

Upstream product

• 110-89-4 piperidine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 
• 19371-31-4 2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine 

Downstream Products

• 16268-88-5 4,6-di(piperidinyl)-1,3,5-triazin-2-amine 
• 54589-69-4 2-hydrazino-4,6-dipiperidino-1,3,5-triazine 
• 65845-84-3 2-(2-(4-chlorobenzylidene)hydrazinyl)-4,6-di(piperidin-1-yl)-1,3,5-triazine 

Relevant articles and documents

A convenient synthesis of triazine-based dendrons and dendrimers via a convergent approach and a study of their interactions with tetrafluoro- benzoquinone

A convenient, efficient and convergent approach to prepare triazine-based dendrons and dendrimers is developed. The steric hindrance resulting from the presence of dioctylamino moieties in the peripheral regions allows the synthesis of soluble dendrons without employing protection and deprotection steps. The triazine-based dendrimers are prepared via reaction of N,N′- dimethylethane-1,2-diamine with the dendrons in a ratio of 1:2. Interactions of the dendrimers with tetrafluorobenzoquinone led to the appearance of new broad bands, red-shifted by approximately 180 nm, in the absorbance spectra. Georg Thieme Verlag Stuttgart.

Application of heterocyclic thiol compound in preparation of antitumor drugs

The heterocyclic thiol compound provided by the invention shows good anti-hepatoma cells. Human breast cancer cells or human non-small cell lung cancer cell activity lays a foundation for screening and development of new drugs, and has good practical value.

Design and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos

s-Triazine is considered a privileged structure, as it is found in several FDA-approved drugs. In the framework of our ongoing medicinal chemistry project based on the use of s-triazine as a scaffold, we synthesized a series of mono- and di-pyrazolyl-s-triazine derivatives and tested them against four human cancer cell lines, namely Human breast carcinoma (MCF 7 and MDA-MB-231), hepatocellular carcinoma (HepG2), colorectal carcinoma (LoVo), and leukemia (K562). The cell viability assay revealed that most of the s-triazine compounds induced cytotoxicity in all four types of human cancer cell lines, however, compounds 4a, and 6g, both of them have a piperidine moiety in their structure were most effective. These two compounds affected the cell viability of cancer cells, with IC50 values within the range between 5 to 9 μM. The cell cycle analysis showed that 4a and 6g induced S and G2/M phase cell cycle arrest in K562 cells. This could be the mechanism by which these molecules induced cytotoxicity in tested cancer cells. The prepared compounds were tested in zebrafish embryos to evaluate in vivo and developmental toxicity of the pyrazolyl-s-triazine derivatives in animals. None of the derivatives were lethal in the concentration range tested.