1391052-76-8

Basic information

• Product Name: benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-
• Synonyms: benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-;N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)-3-hydroxybenzaMide;RofluMilast IMp.E;N-(3,5-Dichloro-4-pyridinyl)-4-(difluoromethoxy)-3-hydroxybenzamide;Roflumilast Impurity E;N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-;Roflumilast Impurity 11
• CAS NO: 1391052-76-8
• Molecular Formula: C₁₃H₈Cl₂F₂N₂O₃
• Molecular Weight: 349.1170264
• EINECS: -0
• Product Categories: Aromatics;Heterocycles;Impurities;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1391052-76-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 397.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.593±0.06 g/cm3(Predicted)
• PKA: 7.59±0.35(Predicted)
• CAS DataBase Reference: benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-(1391052-76-8)
• EPA Substance Registry System: benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy-(1391052-76-8)

Safety Data

• Hazardous Substances Data: 1391052-76-8(Hazardous Substances Data)

Usage

Uses

O-Decyclopropyl Roflumilast is an impurity of Roflumilast (R639700).

Upstream product

• 151103-08-1 4-difluoromethoxy-3-hydroxybenzaldehyde 
• 4837-20-1 4-(difluoromethoxy)benzoic acid 
• 57320-63-5 4-(difluoromethoxy)benzoyl chloride 

Downstream Products

• 162401-32-3 roflumilast 

Relevant articles and documents

PDE4 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS

Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.

Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product

An impurity was isolated from crude synthesized roflumilast and characterized by 1H NMR, 13C NMR, and HR-MS, which confirmed the structure as N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3- hydroxybenzamide. To further verify the str