1393488-62-4

Basic information

• Product Name: 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine
• Synonyms: 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine
• CAS NO: 1393488-62-4
• Molecular Weight: 317.388
• Mol File: 1393488-62-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine(1393488-62-4)
• EPA Substance Registry System: 4-(2-tert-butoxycarbonylamino-propoxy)-quinolin-2-ylamine(1393488-62-4)

Safety Data

• Hazardous Substances Data: 1393488-62-4(Hazardous Substances Data)

Upstream product

• 42712-64-1 2-amino-quinolin-4-ol 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 

Relevant articles and documents

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N,N′-bis(quinolinyl) pyridine-2,6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded DNA. The compounds exhibited growth arrest of cancer cells with detectable selectivity over normal cells. Long-time growth arrest was accompanied by senescence, where telomeric dysfunction is a predominant mechanism together with the accumulation of restricted DNA damage sites in the genome. Our data emphasize the potential of a senescence-mediated anticancer therapy through the use of G-quadruplex targeting small molecules based on the molecular framework of pyridostatin.