1393601-31-4

Basic information

• Product Name: 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide
• Synonyms: 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide
• CAS NO: 1393601-31-4
• Molecular Weight: 528.675
• Mol File: 1393601-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide(1393601-31-4)
• EPA Substance Registry System: 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide(1393601-31-4)

Safety Data

• Hazardous Substances Data: 1393601-31-4(Hazardous Substances Data)

Upstream product

• 4468-47-7 2-methyl-3-oxo-butyronitrile 
• 153624-30-7 2-bromo-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]benzenesulfonamide 
• 153623-86-0 N-(3,4-Dimethyl-5-isoxazolyl)-2-bromo-benzenesulfonamide 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 1393601-46-1 C₃₄H₄₀N₄O₅S 
• 1393601-38-1 C₁₉H₂₁BrN₂ 
• 176961-13-0 2-borono-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 
• 7479-04-1 C₁₂H₁₆N₂ 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 

Relevant articles and documents

Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl) methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

A series of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives (Ia-Il) were synthesized and biologically evaluated. It was found that Ig, the most active compound, antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50 = 8.5, ETA IC50 = 8.9 nM), and was more potent than losartan in RHRs with no significant effect on heart rate. The preliminary structure-activity relationships were also discussed in the present paper.