7479-04-1

Basic information

• Product Name: 1H-Benzimidazole,2-butyl-5-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-butyl-5-methyl-(9CI)
• CAS NO: 7479-04-1
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.26884
• Product Categories: BENZIMIDAZOLE
• Mol File: 7479-04-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 188.4°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 1.88E-05mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 1H-Benzimidazole,2-butyl-5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-butyl-5-methyl-(9CI)(7479-04-1)
• EPA Substance Registry System: 1H-Benzimidazole,2-butyl-5-methyl-(9CI)(7479-04-1)

Safety Data

• Hazardous Substances Data: 7479-04-1(Hazardous Substances Data)

Usage

Class of compound

Benzimidazole derivative (heterocyclic organic compound)

Appearance

Off-white solid

Molecular weight

204.28 g/mol

Use in industry

Building block for synthesis of various medications and biologically active compounds

Use in research and development

Drug discovery and medicinal chemistry

Potential applications

Treatment of various diseases and conditions

Value in drug development

Chemical properties

InChI:InChI=1/C12H16N2/c1-3-4-5-12-13-10-7-6-9(2)8-11(10)14-12/h6-8H,3-5H2,1-2H3,(H,13,14)

Upstream product

• 496-72-0 4-methyl-1,2-diaminobenzene 
• 109-52-4 valeric acid 
• 13820-09-2 trimethyl orthovalerate 

Downstream Products

• 133140-32-6 tert.butyl 4'-[(2-n-butyl-5-methyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate 
• 133140-31-5 tert-butyl 4'-[(2-n-butyl-6-methyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate 
• 1393601-31-4 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 1393601-46-1 C₃₄H₄₀N₄O₅S 
• 1393601-38-1 C₁₉H₂₁BrN₂ 

Relevant articles and documents

Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl) methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

A series of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives (Ia-Il) were synthesized and biologically evaluated. It was found that Ig, the most active compound, antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50 = 8.5, ETA IC50 = 8.9 nM), and was more potent than losartan in RHRs with no significant effect on heart rate. The preliminary structure-activity relationships were also discussed in the present paper.

A highly effective sulfamic acid/methanol catalytic system for the synthesis of benzimidazole derivatives at room temperature

Sulfamic acid/methanol was found to be an efficient catalytic system for the synthesis of benzimidazole compounds through the condensation of o-phenylenediamine with orthoester in high yields at room temperature.