1395078-43-9 Usage
Description
(R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol is a versatile chemical compound derived from ethanol, featuring a tert-butyldimethylsilyloxy group attached to the second carbon and a 4-chloro-3-fluorophenyl group attached to the first carbon. This structure endows the compound with a slightly bulky and polar nature, making it a valuable asset in organic synthesis.
Uses
Used in Organic Synthesis:
(R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol is used as a reagent for the protection and modification of hydroxyl groups in organic synthesis. Its ability to selectively modify specific hydroxyl groups while leaving others untouched is highly beneficial in the preparation of various pharmaceutical and agrochemical compounds.
Used in Pharmaceutical and Agrochemical Industries:
In the Pharmaceutical Industry, (R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol is used as a key intermediate for the synthesis of complex molecules, contributing to the development of new drugs with improved efficacy and selectivity.
In the Agrochemical Industry, (R)-2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol is used as a building block for the creation of novel compounds with potential applications in pest control and crop protection, enhancing agricultural productivity and sustainability.
The tert-butyldimethylsilyloxy group's ease of removal under mild conditions further adds to the compound's utility, making it a preferred choice for chemists working in the field of synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1395078-43-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,5,0,7 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1395078-43:
(9*1)+(8*3)+(7*9)+(6*5)+(5*0)+(4*7)+(3*8)+(2*4)+(1*3)=189
189 % 10 = 9
So 1395078-43-9 is a valid CAS Registry Number.
1395078-43-9Relevant articles and documents
PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
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, (2017/02/24)
The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2
Ren, Li,Grina, Jonas,Moreno, David,Blake, James F.,Gaudino, John J.,Garrey, Rustam,Metcalf, Andrew T.,Burkard, Michael,Martinson, Matthew,Rasor, Kevin,Chen, Huifen,Dean, Brian,Gould, Stephen E.,Pacheco, Patricia,Shahidi-Latham, Sheerin,Yin, Jianping,West, Kristina,Wang, Weiru,Moffat, John G.,Schwarz, Jacob B.
, p. 1976 - 1991 (2015/04/27)
Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.
SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00250, (2013/09/12)
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
