163089-34-7Relevant articles and documents
1,2,3-BENZOTRIAZOLE DERIVATIVES AS ROR GAMMA T MODULATORS
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Page/Page column 57, (2018/03/25)
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, G, L, R1, Rx, Ry, X1, X2, X3, X4, n, p, q and t are
SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00268, (2013/09/12)
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
The rhodium-catalyzed carbene cyclization cycloaddition cascade reaction of vinylsulfonates
Shi, Bairu,Merten, Sandra,Wong, David K. Y.,Chu, John C. K.,Liu, Lok Lok,Lam, Sze Kui,J?ger, Anne,Wong, Wing-Tak,Chiu, Pauline,Metz, Peter
supporting information; experimental part, p. 3128 - 3132 (2010/04/24)
Vinylsulfonates have proved to be excellent dipolarophiles for carbonyl ylides derived from diazoketones in rhodium-catalyzed intramolecular cycloadditions. Polyfunctional substrates, such as 8 and (+)-15, were readily available from hydroxy esters, e.g. 1 and the cyclopenta-1,3-dione 10, respectively, and the resulting polycyclic sultones were formed under mild reaction conditions in high yields with very good diastereoselectivities. A ruthenium-catalyzed asymmetric transfer hydrogenation was found to desymmetrize the meso-cyclopenta-1,3-dione 12 efficiently.