139621-03-7

Basic information

• Product Name: 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide
• Synonyms: 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide
• CAS NO: 139621-03-7
• Molecular Weight: 452.423
• Mol File: 139621-03-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide(139621-03-7)
• EPA Substance Registry System: 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide(139621-03-7)

Safety Data

• Hazardous Substances Data: 139621-03-7(Hazardous Substances Data)

Upstream product

• 190141-28-7 5'-O-(4-methoxytrityl)ribavirin 
• 613-90-1 benzoyl cyanide 
• 36791-04-5 ribavirin 
• 98-88-4 benzoyl chloride 
• 594860-54-5 1-(5-O-tert-butyldimethylsilyl-2,3-di-O-benzoyl-1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide 
• 190141-29-8 1-[2,3-di-O-benzoyl-5-O-(p-monomethoxytrityl)-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxamide 

Relevant articles and documents

Synthesis of Azole Nucleoside 5′-Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases

IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not ass

Nucleotides: Part LII. Synthesis and biological activity of new base- modified (2'- 5')oligoadenylate trimers

Some new (2'- 5')oligoadenylate trimers, i.e., 22-28 containing the antiviral nucleoside ribavirin (= 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole- 3-carboxamide; 7) and the synthetic cytokine 6-(benzylamino)purine riboside (= N6-benzyladenosine; 1) in different positions of the trimer, have been synthesized by the posphotriester method. The selectively blocked nucleosides 2-6 and 8-11 and the 2'-phosphodiesters 13 and 14, used for the oligonucleotide syntheses, were synthesized from the corresponding unprotected ribonucleosides 1 and 7, and isolated by silica-gel column chromatography. The fully deblocked trimers 22-28 were purified by ion- exchange chromatography on DEAE-Servavell 23-SS. The newly synthesized compounds were characterized by physical means. The ability of synthesized trimers to inhibit HIV-1 replication and to improve RNase L activation were investigated Some of the synthesized trimers showed also biological inhibition of HIV-1 reverse transcriptase and HIV-1-induced syncytia formation. It was shown that Ado(Bn)-containing trimers inhibited HIV-1- induced syncytia formation > 1500-fold, independently of the position of the Ado(Bn) residue in the oligomer chain.