190141-28-7

Basic information

• Product Name: 5'-O-(4-methoxytrityl)ribavirin
• Synonyms: 5'-O-(4-methoxytrityl)ribavirin
• CAS NO: 190141-28-7
• Molecular Weight: 516.554
• Mol File: 190141-28-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5'-O-(4-methoxytrityl)ribavirin(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4-methoxytrityl)ribavirin(190141-28-7)
• EPA Substance Registry System: 5'-O-(4-methoxytrityl)ribavirin(190141-28-7)

Safety Data

• Hazardous Substances Data: 190141-28-7(Hazardous Substances Data)

Upstream product

• 14470-28-1 mono-4-methoxytrityl chloride 
• 36791-04-5 ribavirin 

Downstream Products

• 1171006-25-9 2',3'-di-O-levulinoyl-5'-O-(4-methoxytrityl)ribavirin 
• 139621-03-7 1-(2,3-di-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide 

Relevant articles and documents

Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5′-monophosphates bearing a biodegradable protecting group

Ribavirin and 2′-O-methylcytidine 5′-phosphoramidates derived from l-alanine methyl ester bearing either an O-phenyl or a biodegradable O-[3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl] or O-[3-(acetyloxymethoxy)-2,2- bis(ethoxycarbonyl)propyl] protecting group were prepared. The kinetics of the deprotection of these pro-drugs by porcine liver esterase and by a whole cell extract of human prostate carcinoma was studied by HPLC-ESI-MS/MS. The 3-(acetyloxymethoxy)-2,2-bis(ethoxycarbonyl)propyl and 3-(acetyloxy)-2,2- bis(ethoxycarbonyl)propyl groups were readily removed releasing the l-alanine methyl ester phosphoramidate nucleotide, the deprotection of the 3-(acetyloxymethoxy) derivative being approximately 20 times faster. The chemical stability of the 2′-O-methylcytidine pro-drugs was additionally determined over a pH range from 7.5 to 10.

PROTECTED NUCLEOTIDE ANALOGS

Disclosed herein are nucleotide analogs with one or more protecting groups, methods of synthesizing nucleotide analogs with one or more protecting groups and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic