1398623-73-8Relevant articles and documents
Syntheses of siderophore-drug conjugates using a convergent thiol-maleimide system
Juarez-Hernandez, Ral E.,Miller, Patricia A.,Miller, Marvin J.
supporting information, p. 799 - 803 (2013/01/15)
Three siderophore-drug conjugates (sideromycins) were synthesized by preparation of a maleimide linked derivative of the siderophore desferrioxamine B and reacting the corresponding Ga3+-complex with freshly prepared thiol-containing antibiotics: loracarbef, ciprofloxacin, and nadifloxacin. The conjugates and their synthetic precursors were tested against a broad panel of bacteria and were found to display Gram-positive selective, growth inhibitory activity (μM), indicating that this approach is suitable for the convergent syntheses and screening of novel sideromycins.