1399843-70-9Relevant articles and documents
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis
Stappenbeck, Frank,Xiao, Wei,Epperson, Matt,Riley, Mariko,Priest, Aaron,Huang, Danwen,Scott Thies, R.,Farouz, Francine,Nguyen, Khanhlinh,Jung, Michael E.
, p. 5893 - 5897,5 (2012)
Localized induction of bone formation is essential during orthopedic procedures that involve skeletal repair, such as surgical treatment of non-union bone fractures and degenerative disk disease. Herein we disclose the synthesis and biological evaluation of novel oxysterol derivatives designed as anabolic bone growth agents. Structure-activity relationship studies of oxysterol 4 have identified analogues such as 18, 21 and 30. These new analogues are characterized by higher potency in an osteoblast differentiation assay and/or by increased metabolic stability in human liver microsomes. Oxysterols 4, 18 and 21 were evaluated in vivo in a rat spinal fusion model.
