14003-18-0Relevant articles and documents
Synthetic and Theoretical Studies on the Reduction of Electron Withdrawing Group Conjugated Olefins Using the Hantzsch 1,4-Dihydropyridine Ester
Garden, Simon J.,Werneck Guimaraes, Cristiano Ruch,Correa, Marilza B.,Fernandes de Oliveira, Cesar Augusto,Da Cunha Pinto, Angelo,Bicca de Alencastro, Ricardo
, p. 8815 - 8822 (2003)
The Hantzsch 1,4-dihydropyridine ester (1) has been observed to be a useful selective reducing agent for the reduction of electron-withdrawing conjugated double bonds. The rate of this reaction was observed to be dependent upon the nature of the conjugate
Bioreduction of the C=C double bond with Pseudomonas monteilii ZMU-T17: One approach to 3-monosubstituted oxindoles
Zhao, Jia,Guan, Shuicheng,Zhou, Xiaojian,Han, Wenyong,Cui, Baodong,Chen, Yongzheng
, p. 3098 - 3104 (2016)
An efficient whole cell-mediated bioreduction of 3-methylene-2-oxindoles has been developed, affording a range of 3-monosubstituted oxindoles in moderate to good yields (41-82%) with Pseudomonas monteilii ZMU-T17 as biocatalyst. Additionally, a possible reaction pathway for this bioreduction of C=C double bond was proposed.
Synthesis of 2,6′-dioxo-1′,5′,6′,7′- tetrahydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-5′- carbonitriles via a one-pot, three-component reaction in water
Rahmati, Abbas,Kenarkoohi, Tahmineh,Khavasi, Hamid Reza
, p. 657 - 664 (2012)
A one-pot, three-component condensation reaction of an isatin, aminopyrazole, and alkyl cyanoacetate in water to give 2,6′-dioxo- 1′,5′,6′,7′-tetrahydrospiro[indoline-3, 4′-pyrazolo[3,4-b]pyridine]-5′-carbonitrile with good yields, at 90 C, using a Et3N as catalyst, is described.
Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon-carbon double bond formation
Tan, Zhi-Yu,Wu, Ke-Xin,Huang, Lu-Shan,Wu, Run-Shi,Du, Zheng-Yu,Xu, Da-Zhen
supporting information, p. 332 - 335 (2020/02/13)
The iron-catalyzed cross-dehydrogenative coupling (CDC) of C(sp3)-H/C(sp3)-H bonds to afford olefins by 4H elimination is described. This method employs air (molecular oxygen) as an ideal oxidant, and is performed under mild, ligand-free and base-free conditions. H2O is the only byproduct. Good tolerance of functional groups and high yields have also been achieved. Preliminary mechanistic investigations suggest that the present transformation involves a radical process.
Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast
Rossetti, Arianna,Sacchetti, Alessandro,Bonfanti, Marta,Roda, Gabriella,Rainoldi, Giulia,Silvani, Alessandra
, p. 4584 - 4590 (2017/07/11)
3-Substituted oxindoles are very interesting molecules both for their potential biological activity and for their role as starting materials toward more complex oxindole-based structures. These molecules can be prepared by the reduction of a 3-ylidene oxi
