55711-62-1

Basic information

• Product Name: isatine 3-benzoylhydrazone
• Synonyms: isatine 3-benzoylhydrazone
• CAS NO: 55711-62-1
• Molecular Weight: 265.271
• Mol File: 55711-62-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: isatine 3-benzoylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: isatine 3-benzoylhydrazone(55711-62-1)
• EPA Substance Registry System: isatine 3-benzoylhydrazone(55711-62-1)

Safety Data

• Hazardous Substances Data: 55711-62-1(Hazardous Substances Data)

Upstream product

• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 613-94-5 benzoic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 93-58-3 benzoic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 
• 1422157-55-8 tert-butyl N-[[chloro(phenyl)methylene]amino]carbazate 
• 91-56-5 indole-2,3-dione 
• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 

Downstream Products

• 125299-17-4 2-Phenyl-<1,3,4>oxadiazino<5,6-b>indole 
• 105062-03-1 dichloro(2-isatin-3-benzoylhydrazone)cadmium(II) 

Relevant articles and documents

Synthesis, in silico, in vitro and in vivo evaluations of isatin aroylhydrazones as highly potent anticonvulsant agents

In this study, a series of new isatin aroylhydrazones (5a-e and 6a-e) was synthesized and evaluated for their anticonvulsant activities. The (Z)-configuration of compounds was confirmed by 1H NMR. In vivo studies using maximal electroshock (MES) and pentylenetetrazole (PTZ) models of epilepsy in mice revealed that while most of compounds had no effect on chemically-induced seizures at the higher dose of 100 mg/kg but showed significant protection against electrically-induced seizures at the lower dose of 5 mg/kg. Certainly, N-methyl analogs 6a and 6e were found to be the most effective compounds, displaying 100% protection at the dose of 5 mg/kg. Protein binding and lipophilicity (logP) of the selected compounds (6a and 6e) were also determined experimentally. In silico evaluations of title compounds showed acceptable ADME parameters, and drug-likeness properties. Distance mapping and docking of the selected compounds with different targets proposed the possible action of them on VGSCs and GABAA receptors. The cytotoxicity evaluation of 6a and 6e against SH-SY5Y and Hep-G2 cell lines indicated safety profile of compounds on the neuronal and hepatic cells.

Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins

Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and their structures were confirmed using spectroscopic methods such as NMR, IR

Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents

Two series of new 2,3-dihydrooxazole-spirooxindole derivatives were efficiently synthesized starting from N′-(2-oxoindolin-3-ylidene) benzohydrazide/N′-(2-oxoindolin-3-ylidene)-2-phenoxyacetohydrazide using designed synthetic route. Newly synthesized 2,3-