1400992-23-5

Basic information

• Product Name: 6-(4-aminophenoxy)-3-hydroxy-3-(trifluoromethyl)indolin-2-one
• Synonyms: 6-(4-aminophenoxy)-3-hydroxy-3-(trifluoromethyl)indolin-2-one
• CAS NO: 1400992-23-5
• Molecular Weight: 324.259
• Mol File: 1400992-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-aminophenoxy)-3-hydroxy-3-(trifluoromethyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-aminophenoxy)-3-hydroxy-3-(trifluoromethyl)indolin-2-one(1400992-23-5)
• EPA Substance Registry System: 6-(4-aminophenoxy)-3-hydroxy-3-(trifluoromethyl)indolin-2-one(1400992-23-5)

Safety Data

• Hazardous Substances Data: 1400992-23-5(Hazardous Substances Data)

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 2657-87-6 3,4'-diaminodiphenyl ether 

Relevant articles and documents

Diverse reactivity in microwave-promoted catalyst-free coupling of substituted anilines with ethyl trifluoropyruvate and biological evaluation

Diverse reactivity by coupling of substituted anilines with ethyl trifluoropyruvate was developed under microwave irradiation without catalysts to generate 3-trifluoromethyl-3-hydroxy oxindoles, aromatic hydroxy trifluoromethyl esters, and 1,2-dicarbonyl compounds in a fast and efficient manner. The plausible mechanism for obtaining different products was proposed. Furthermore, the anti-HIV activity of aromatic hydroxy trifluoromethyl esters was first reported. The best inhibitory activity against wild-type HIV-1 IIIB was exemplified by trifluoromethyloxindole 3q with an IC50 = 5.8 μM, which also displayed potential activity against Y181C mutant virus with an IC50 = 7.5 μM. More significantly, the activities of oxindoles 3q and 3r to inhibit K103N/Y181C double mutant HIV-1 reverse transcriptase (RT) are probably similar to that of the second-generation nonnucleoside inhibitor HBY 097 by docking calculation.