141449-85-6

Basic information

• Product Name: 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE
• Synonyms: HEXAHYDRO-PYRROLO[3,4-C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE;2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE HYDROCHLORIDE;2-Boc-hexahydro-pyrrpol[3,4-c]pyrrole;Pyrrolo[3,4-c]Pyrrole-2(1H)-Ca;2-Boc-octahydropyrrolo[3,4-c]pyrrole;4-c]pyrrole-2(1H)-carboxylate;tert-butyl hexahydropyrrolo[3
• CAS NO: 141449-85-6
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.29
• Product Categories: Amines and Anilines;Heterocycles
• Mol File: 141449-85-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 293.115 °C at 760 mmHg
• Flash Point: 131.071 °C
• Appearance: /
• Density: 1.05 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.72±0.20(Predicted)
• CAS DataBase Reference: 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE(141449-85-6)
• EPA Substance Registry System: 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE(141449-85-6)

Safety Data

• Hazardous Substances Data: 141449-85-6(Hazardous Substances Data)

Usage

General Description

2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE is a chemical compound with the molecular formula C13H20N2O2. It is a derivative of pyrrolo[3,4-c]pyrrole, a heterocyclic compound, and is commonly used as a building block in organic synthesis. The "2-BOC" in its name refers to the tert-butoxycarbonyl (BOC) protecting group attached to the 2-position of the molecule, which serves to prevent unwanted reactions at that site during chemical transformations. 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE is widely employed in the pharmaceutical and agrochemical industries for the synthesis of various biologically active molecules, making it a valuable and versatile chemical building block.

InChI:InChI=1/C11H20N2O2/c1-11(2,3)15-10(14)13-6-8-4-12-5-9(8)7-13/h8-9,12H,4-7H2,1-3H3

Upstream product

• 186202-73-3 tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 86732-22-1 2-benzyloctahydropyrrolo[3,4-c]pyrrole 
• 848591-86-6 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 

Downstream Products

• 949558-93-4 tert-butyl 5-(4-(4-amino-2-fluorophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 666852-52-4 2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[2-(5-t-butoxycarbonyl-octahydropyrrolo[3,4-c]pyrrol-2-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole 
• 848592-56-3 tert-butyl 5-(3-methoxyphenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 848591-87-7 5-(6-phenyl-pyridazin-3-yl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester 
• 851526-96-0 5-(1-methylsulfanyl-3-oxo-3-phenyl-propenyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester 
• 1048108-76-4 tert-butyl 5-methylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1048106-89-3 5-[(1S,4R,5S,15R)-5-(3,5-difluoro-benzyl)-4-hydroxy-7-oxo-14-oxa-2,6-diaza-tricyclo[13.6.1.0(16,21)]docosa-11,16⁽²¹⁾,17,19-tetraen-19-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester 
• 1202067-19-3 5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]hexahydropyrrolo[3,4-c]pyrrole-2-carboxylic acid terf-butyl ester 
• 1224171-23-6 tert-butyl 5-(5-(2-(4-chlorophenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)pyridin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1095708-38-5 tert-Butyl 5-[3-(2-aminopyrid-4-yl)-2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]hexahydropyrrolo[3,4-c]pyrrole-2-carboxylate 
• 1293285-16-1 tert-butyl 5-{[2-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1293285-15-0 tert-butyl 5-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 

Relevant articles and documents

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOAL KANES

The present invention relates to compounds of the following formula (I) that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).