186202-73-3

Basic information

• Product Name: 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole
• Synonyms: 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole;2-Boc-5-Benzylhexahydropyrrolo[3,4-c]pyrrole;tert-Butyl 5-benzyl-octahydropyrrolo-[3,4-c]pyrrole-2-carboxylate;5-Benzyl-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester;tert-Butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
• CAS NO: 186202-73-3
• Molecular Formula: C₁₈H₂₆N₂O₂
• Molecular Weight: 302.41124
• Mol File: 186202-73-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole(186202-73-3)
• EPA Substance Registry System: 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole(186202-73-3)

Safety Data

• Hazardous Substances Data: 186202-73-3(Hazardous Substances Data)

Usage

Description

5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole is a pyrrole derivative featuring a hexahydro-pyrrolo[3,4-C]pyrrole ring system with a benzyl group and a Boc (tert-butoxycarbonyl) protecting group at the 2 position. 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole holds potential in medicinal chemistry, particularly for the development of drugs targeting the central nervous system, and serves as a building block in organic synthesis for constructing complex molecules. The Boc protecting group enhances stability and allows for selective reactivity manipulation.

Uses

Used in Medicinal Chemistry:
5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole is used as a potential drug candidate for the development of therapeutic agents targeting the central nervous system due to its unique structure and properties.
Used in Organic Synthesis:
5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole is used as a building block in organic synthesis for the construction of complex molecules, taking advantage of its stability and selective reactivity provided by the Boc protecting group.
Used in Research and Development:
5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole is utilized in research and development for the discovery of new therapeutic agents and useful intermediates in chemical synthesis, further expanding its applications in the pharmaceutical and chemical industries.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 86732-22-1 2-benzyloctahydropyrrolo[3,4-c]pyrrole 
• 848591-86-6 5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 141449-85-6 tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 100-52-7 benzaldehyde 

Downstream Products

• 141449-85-6 tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1293285-14-9 tert-butyl 5-{[2-(4H-1,2,4-triazol-3-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrole-2(1 H)-carboxylate 
• 1293280-54-2 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylthiophen-2-yl)carbonyl]octahydropyrrolo[3 ,4-c]pyrrole 
• 1293280-52-0 2-(4,6-dimethylpyrimidin-2-yl)-5-[(1-phenyl-1H-pyrazol-5-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole 
• 1293280-55-3 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-phenylfuran-2-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole 
• 1293280-56-4 2-(4,6-dimethylpyrimidin-2-yl)-5-{[2-(1H-1,2,4-triazol-5-yl)phenyl]carbonyl}octahydro-pyrrolo[3,4-c]pyrrole 
• 1293280-57-5 2-(4,6-dimethylpyrimidin-2-yl)-5-{[3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl} octahydropyrrolo[3,4-c]pyrrole 
• 1293281-49-8 [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone 
• 1293282-91-3 6-[5-{[2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-2-methylpyrimidin-4(3H)-one 
• 1293286-18-6 methyl 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl )hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 1293283-00-7 2-(5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl )-4-(trifluoromethyl )pyrimidine-5-carboxylic acid 
• 1293283-20-1 2-(4,6-dimethylpyrimidin-2-yl)-5-[(3-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]octahydropyrrolo[3,4-c]pyrrole 
• 1293284-63-5 (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)methanone 
• 1293284-64-6 5-(2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid tert-butyl ester 

Relevant articles and documents

Identification of benzothiazones containing a hexahydropyrrolo[3,4-: C] pyrrol moiety as antitubercular agents against MDR-MTB

IMB1603, a spiro-benzothiazone compound discovered by our lab, displayed potent anti-MTB activity in vitro and in vivo. In this study, we reported a series of new BTZs containing the hexahydropyrrolo[3,4-c]pyrrol moiety based on the structure of IMB1603. Among them, BTZs 11 and 24 displayed potent anti-MTB (MIC -1), and low cytotoxicity (CC50 > 200 μM), suggesting BTZs 11 and 24 may serve as promising candidates for further study. The molecular docking study of 11 toward DprE was also investigated, and revealed that 11 mimicked the binding pattern of PBTZ169 in the active site of DprE1.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.