1415328-95-8

Basic information

• Product Name: Phth-PEG₄-OSu
• CAS NO: 1415328-95-8
• Molecular Weight: 508.482
• Mol File: 1415328-95-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phth-PEG₄-OSu(CAS DataBase Reference)
• NIST Chemistry Reference: Phth-PEG₄-OSu(1415328-95-8)
• EPA Substance Registry System: Phth-PEG₄-OSu(1415328-95-8)

Safety Data

• Hazardous Substances Data: 1415328-95-8(Hazardous Substances Data)

Usage

General Description

Phth-PEG4-OSu is a chemical compound used in bioconjugation and bio-catalyst applications. It is composed of a phthalimide group, a polyethylene glycol (PEG) chain with four repeating ethylene glycol units, and an N-hydroxysuccinimide (NHS) ester. The phthalimide group serves as a protecting group for a primary amine, while the PEG chain provides hydrophilicity and a flexible spacer for conjugation. The NHS ester group is commonly used for amine-reactive crosslinkers and labeling reagents, making Phth-PEG4-OSu a versatile tool for chemical modification of biomolecules and surfaces in biomedical research and drug delivery applications.

Upstream product

• 581065-94-3 tert-butyl 3-[2-(2-{2-[2-(toluene-4-sulfonyloxy)-ethoxy]ethoxy}ethoxy)ethoxy]propionate 
• 4792-15-8 Pentaethylene glycol 
• 539820-48-9 2-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)isoindoline-1,3-dione 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1415246-35-3 AS₂₆₉ 
• 1415246-72-8 C₅₅H₈₄N₆O₁₄ 
• 1415246-41-1 tetra ethyleneglycol 
• 524-38-9 N-hydroxyphthalimide 
• 1415328-82-3 C₂₃H₃₃NO₉ 
• 518044-32-1 tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate 
• 1415328-83-4 C₁₉H₂₅NO₉ 
• 112-60-7 Tetraethylene glycol 

Downstream Products

• 1415328-98-1 C₄₄H₅₅N₇O₁₆ 

Relevant articles and documents

Recruiting cytotoxic T cells to folate-receptor-positive cancer cells

A Fab-ulous killer: An anti-CD3 Fab-folate conjugate that targets cytotoxic Tcells to folate-receptor-positive (FR+) tumors results in efficient killing of tumor cells by activated Tcells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields. Copyright

ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES AND THEIR USES

Described herein are novel anti-CD3 Folate antibodies and uses thereof in the treatment of diseases or conditions that would benefit from such.

PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES

This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αPSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αPSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.