1415328-98-1

Basic information

• Product Name: C₄₄H₅₅N₇O₁₆
• Synonyms: C₄₄H₅₅N₇O₁₆
• CAS NO: 1415328-98-1
• Molecular Weight: 937.958
• Mol File: 1415328-98-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₄₄H₅₅N₇O₁₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₄H₅₅N₇O₁₆(1415328-98-1)
• EPA Substance Registry System: C₄₄H₅₅N₇O₁₆(1415328-98-1)

Safety Data

• Hazardous Substances Data: 1415328-98-1(Hazardous Substances Data)

Upstream product

• 539820-48-9 2-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)isoindoline-1,3-dione 
• 159857-79-1 (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide 
• 1415328-95-8 Phth-PEG₄-OSu 
• 1415246-35-3 AS₂₆₉ 
• 1415246-72-8 C₅₅H₈₄N₆O₁₄ 
• 1415246-41-1 tetra ethyleneglycol 
• 1415328-83-4 C₁₉H₂₅NO₉ 
• 1415328-82-3 C₂₃H₃₃NO₉ 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 
• 1415328-97-0 C₃₇H₅₂N₆O₁₂ 
• 518044-32-1 tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate 
• 112-60-7 Tetraethylene glycol 

Downstream Products

• 1415329-00-8 C₇₉H₁₁₆N₁₂O₁₉S 
• 1415329-17-7 C₇₇H₁₁₅N₁₁O₂₁ 

Relevant articles and documents

ANTI-CD70 ANTIBODY DRUG CONJUGATES

This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αCD70 antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αCD70 antibodies of the invention are conjugated to one or more toxins. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.

ANTIBODY-DRUG CONJUGATES

Disclosed are anti-5T4 antibody drug conjugates with an improved pharmacokinetic profile and methods for preparing and using the same. In one embodiment, the antibody-drug conjugate has the formula Ab-(D)p, wherein Ab is an anti-5T4 antibody comprising a non- natural amino acid; D is a dolastatin linker derivative; and p is from about 1 to about 8.