1416226-23-7

Basic information

• Product Name: C₁₆H₁₄Cl₂O₃
• CAS NO: 1416226-23-7
• Molecular Weight: 325.191
• Mol File: 1416226-23-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄Cl₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄Cl₂O₃(1416226-23-7)
• EPA Substance Registry System: C₁₆H₁₄Cl₂O₃(1416226-23-7)

Safety Data

• Hazardous Substances Data: 1416226-23-7(Hazardous Substances Data)

Upstream product

• 1403563-07-4 C₁₆H₁₄Cl₂O 
• 99-91-2 para-chloroacetophenone 
• 16197-82-3 1,3-bis(4-chlorophenyl)but-2-en-1-one 

Relevant articles and documents

Synthesis and antimalarial activity of 3,3-spiroanellated 5,6-disubstituted 1,2,4-trioxanes

Novel 3,3-spiroanellated 5-aryl, 6-arylvinyl-substituted 1,2,4-trioxanes 19-34 have been synthesized and appraised for their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice by oral route at doses ranging from 96 mg/kg × 4 days to 24 mg/kg × 4 days. The most active compound of the series (compound 25) provided 100% protection at 24 mg/kg × 4 days, and other 1,2,4-trioxanes 22, 26, 27, and 30 also showed promising activity. In this model, β-arteether provided 100 and 20% protection at 48 mg/kg × 4 days and 24 mg/kg × 4 days, respectively, by oral route. Compound 25 displayed a similar in vitro pharmacokinetic profile to that of reference drug β-arteether. The activity results demonstrated the importance of an aryl moiety at the C-5 position on the 1,2,4-trioxane pharmacophore.