1417449-11-6

Basic information

• Product Name: ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate
• Synonyms: ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate
• CAS NO: 1417449-11-6
• Molecular Weight: 334.418
• Mol File: 1417449-11-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate(1417449-11-6)
• EPA Substance Registry System: ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate(1417449-11-6)

Safety Data

• Hazardous Substances Data: 1417449-11-6(Hazardous Substances Data)

Upstream product

• 613-85-4 (2,5-dimethylphenyl)hydrazine 
• 93-55-0 1-phenyl-propan-1-one 
• 95-92-1 oxalic acid diethyl ester 
• 56737-78-1 2,5-dimethylphenylhydrazine hydrochloride 

Downstream Products

• 1426436-63-6 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

'One-pot' synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction

A concise 'one-pot' synthesis of a variety of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates has been developed in moderate to good yields with excellent regioselectivity. Less cost lithium tert-butoxide has been identified as a base for sterically hindered Claisen condensation to efficiently generate the labile 3-substituted 4-aryl-2,4-diketoesters. Furthermore, extensive studies lead to a 'one-pot' process by combination of the Claisen condensation and the Knorr reaction for the synthesis of highly valuable 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates.