56737-78-1

Basic information

• Product Name: 2,5-Dimethylphenylhydrazine hydrochloride
• Synonyms: 2,5-DIMETHYLPHENYLHYDRAZINE HCL;2,5-DIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE;2,5-Dimethylphenylhydrazine hydrochloride 98%;2,5-DIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE, 98+%;2-(Hydrazino)-m-xylene hydrochloride
• CAS NO: 56737-78-1
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.66
• EINECS: 1592732-453-0
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;API intermediates;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 56737-78-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 205 °C (dec.)(lit.)
• Boiling Point: 232.1 °C at 760 mmHg
• Flash Point: 107.4 °C
• Appearance: white to light yellow crystal powde
• Density: 1.058g/cm³
• Vapor Pressure: 0.0602mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• BRN: 6118180
• CAS DataBase Reference: 2,5-Dimethylphenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethylphenylhydrazine hydrochloride(56737-78-1)
• EPA Substance Registry System: 2,5-Dimethylphenylhydrazine hydrochloride(56737-78-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 56737-78-1(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2,5-Dimethylphenylhydrazine, HCl

InChI:InChI=1/C8H12N2.ClH/c1-6-3-4-7(2)8(5-6)10-9;/h3-5,10H,9H2,1-2H3;1H

Upstream product

• 95-78-3 2,5-Dimethylaniline 

Downstream Products

• 270585-06-3 1-(2,5-dimethyl-phenyl)-5-isopropyl-3-methoxymethyl-1H-pyrazole 
• 912963-96-3 adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide 
• 882227-25-0 1-(2,5-dimethylphenyl)-3-methyl-5-aminopyrazole 
• 1252577-78-8 C₁₇H₁₇N₅O 
• 1290143-13-3 C₁₇H₁₇N₅O 
• 1417449-11-6 ethyl 1-(2,5-dimethylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate 
• 1448583-05-8 C₃₁H₄₂N₂O₂ 
• 1566598-81-9 ethyl 1-(2,5-dimethylphenyl)-4,5-diphenyl-1H-pyrazole-3-carboxylate 
• 1578191-14-6 (E)-4-((2-(2,5-dimethylphenyl)hydrazono)methyl)-1-phenyl-1H-1,2,3-triazole 
• 95911-73-2 3-hydroxy-2-(2',5'-dimethylphenyl)-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors

A series of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanones (8a-p, 9a-p) and ketoxime (10c) derivatives were designed and synthesized as antitubulin agents. All of the target compounds were evaluated for the in vitro anti-proliferative activities against three tumor cell lines (A549, HT-1080, SGC-7901). The most promising compounds in this class were (1-(p-tolyl)-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone (9c) and its ketoxime derivative (10c), which significantly inhibited tumor cells growth with IC50 value of 0.054–0.16 μM. Meanwhile, compound 9c exhibited effectively inhibitory activity of tubulin polymerization. Consistent with its antitubulin activity, compound 9c could destructively damage microtubule network and arrest SGC-7901 cell cycle at G2/M phase significantly. The structure-activity relationship (SAR) and conformational analysis indicate that methyl group at C4-position of C-ring is critical for the activities and the amino group at the C5-position of B-ring plays a negative role in maintaining bioactivity. Furthermore, a molecular docking study was performed to elucidate its binding mode at the colchicine site in the tubulin heterodimer.