912963-96-3

Basic information

• Product Name: adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide
• Synonyms: adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide
• CAS NO: 912963-96-3
• Molecular Weight: 298.428
• Mol File: 912963-96-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide(912963-96-3)
• EPA Substance Registry System: adamantane-1-carboxylic acid N'-(2,5-dimethylphenyl)hydrazide(912963-96-3)

Safety Data

• Hazardous Substances Data: 912963-96-3(Hazardous Substances Data)

Upstream product

• 2094-72-6 1-Adamantanecarbonyl chloride 
• 56737-78-1 2,5-dimethylphenylhydrazine hydrochloride 

Relevant articles and documents

Structure-activity relationship studies on N′-aryl carbohydrazide P2X7 antagonists

N′-Aryl acyl hydrazides were identified as P2X7 receptor antagonists. Structure-activity relationship (SAR) studies evaluated functional activity by monitoring calcium flux inhibition in cell lines expressing recombinant human and rat P2X7 receptors. Selected analogs were assayed in vitro for their capacity to inhibit release of cytokine IL-1β. Compounds with potent antagonist function were evaluated in vivo using the zymosan-induced peritonitis model. A representative compound effectively attenuated mechanical allodynia in a rat model of neuropathic pain.