1417787-27-9

Basic information

• Product Name: diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate
• Synonyms: diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate
• CAS NO: 1417787-27-9
• Molecular Weight: 517.568
• Mol File: 1417787-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate(1417787-27-9)
• EPA Substance Registry System: diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate(1417787-27-9)

Safety Data

• Hazardous Substances Data: 1417787-27-9(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 183194-25-4 [[2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy]methyl]phosphonic acid bis(1-methylethyl)ester 
• 630107-95-8 2-[(diisopropoxyphosphoryl)methoxy]ethyl 4-methylbenzene-1-sulfonate 
• 162612-60-4 diisopropyl (2-hydroxyethoxy)methanephosphonate 
• 162612-58-0 diisopropyl <(2-acetoxyethoxy)methyl>phosphonate 
• 10310-21-1 2-Amino-6-chloropurin 

Relevant articles and documents

Diversity oriented efficient access of trisubstituted purines via sequential regioselective Mitsunobu coupling and SNAr based C 6 functionalizations

An efficient protocol for the syntheses of diverse 2,6,7- and 2,6,9-trisubstituted purines is reported starting from the guanine precursor, 2amino-6-chloropurine nucleoside through subsequent regioselective, high yielding Mitsunobu coupling and nucleophilic substitutions at C6 with versatile primary and secondary amines. A wide range of 2,6,7- and 2,6,9-trisubstituted purines were accessible in good to excellent yields with remarkable functional group tolerance. Moreover, solvent-free, large scale synthesis of precursors 2 & 3 and facile preparation of organophosphorus side chains 4 & 5 were also accomplished with excellent yields.