162612-58-0

Basic information

• Product Name: Phosphonic acid, [[2-(acetyloxy)ethoxy]methyl]-, bis(1-methylethyl) ester
• CAS NO: 162612-58-0
• Molecular Formula: C11H23O6P
• Molecular Weight: 282.274
• Mol File: 162612-58-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [[2-(acetyloxy)ethoxy]methyl]-, bis(1-methylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [[2-(acetyloxy)ethoxy]methyl]-, bis(1-methylethyl) ester(162612-58-0)
• EPA Substance Registry System: Phosphonic acid, [[2-(acetyloxy)ethoxy]methyl]-, bis(1-methylethyl) ester(162612-58-0)

Safety Data

• Hazardous Substances Data: 162612-58-0(Hazardous Substances Data)

Upstream product

• 116-17-6 triisopropyl phosphite 
• 40510-88-1 1-acetoxy-2-chloromethoxyethane 

Downstream Products

• 1417787-41-7 diisopropyl{2-[2-amino-6-(4-benzylpiperazine-1-yl)-7H-purine-7-yl]ethoxy}methylphosphonate 
• 1417787-43-9 diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-7H-purine-7-yl]ethoxy}methylphosphonate 
• 1417787-48-4 diisopropyl{2-[2-amino-6-(benzylamino)-7H-purine-7-yl]ethoxy}methylphosphonate 
• 1417787-51-9 diisopropyl{2-[2-amino-6-(cyclohexylamino)-7H-purine-7-yl]ethoxy}methyl-phosphonate 
• 1417787-27-9 diisopropyl{2-[2-amino-6-(4-phenylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate 
• 1417787-28-0 diisopropyl{2-[2-amino-6-(4-benzylpiperazine-1-yl)-9H-purine-9-yl]ethoxy}methylphosphonate 
• 630107-97-0 2,4-diamino-5-benzyl-1-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}pyrimidin-6(1H)-one 
• 630108-01-9 2,4-diamino-1-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-5-phenylpyrimidin-6(1H)-one 
• 630108-12-2 2,4-diamino-5-benzyl-6-[2-(diisopropoxyphosphorylmethoxy)ethoxy]pyrimidine 
• 630108-16-6 2,4-diamino-6-[2-(diisopropoxyphosphorylmethoxy)ethoxy]-5-phenylpyrimidine 
• 630107-95-8 2-[(diisopropoxyphosphoryl)methoxy]ethyl 4-methylbenzene-1-sulfonate 

Relevant articles and documents

Diversity oriented efficient access of trisubstituted purines via sequential regioselective Mitsunobu coupling and SNAr based C 6 functionalizations

An efficient protocol for the syntheses of diverse 2,6,7- and 2,6,9-trisubstituted purines is reported starting from the guanine precursor, 2amino-6-chloropurine nucleoside through subsequent regioselective, high yielding Mitsunobu coupling and nucleophilic substitutions at C6 with versatile primary and secondary amines. A wide range of 2,6,7- and 2,6,9-trisubstituted purines were accessible in good to excellent yields with remarkable functional group tolerance. Moreover, solvent-free, large scale synthesis of precursors 2 & 3 and facile preparation of organophosphorus side chains 4 & 5 were also accomplished with excellent yields.