14178-42-8

Basic information

• Product Name: Benzamide, N-(1-oxido-2-pyridinyl)-
• Synonyms: 2-benzamidopyridine 1-oxide;2-Benzamino-pyridin-1-oxid
• CAS NO: 14178-42-8
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.224
• Mol File: 14178-42-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 121-123 °C
• Boiling Point: 359.3±15.0 °C(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzamide, N-(1-oxido-2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(1-oxido-2-pyridinyl)-(14178-42-8)
• EPA Substance Registry System: Benzamide, N-(1-oxido-2-pyridinyl)-(14178-42-8)

Safety Data

• Hazardous Substances Data: 14178-42-8(Hazardous Substances Data)

Upstream product

• 4589-12-2 N-(pyrid-2-yl)benzamide 
• 100136-42-3 1-benzoyloxy-1H-pyridin-2-one-imine 
• 64-17-5 ethanol 
• 504-29-0 2-aminopyridine 
• 14150-95-9 2-aminopyridine N-oxide 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 5255-67-4 ethyl 2-pyridinylcarbamate 

Downstream Products

• 4589-12-2 N-(pyrid-2-yl)benzamide 
• 1557025-33-8 2-(2-methoxybenzamido)pyridine 1-oxide 

Relevant articles and documents

Nickel-catalyzed regioselective arylation of aromatic amides with aryl iodides enabled by an: N, O -bidentate directing group

A bidentate directing group enabled regioselective arylation of C(sp2)-H bonds in aromatic carboxamides with aryl iodides under nickel-catalysis is reported, which provides the corresponding products in moderate to good yields. This protocol using the inexpensive and low-toxic Ni catalyst can tolerate a wide range of functional groups.

Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent

The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.

Cobalt-catalyzed C(sp2)-H alkoxylation of aromatic and olefinic carboxamides

The cobalt-catalyzed alkoxylation of C(sp2)-H bonds in aromatic and olefinic carboxamides has been developed. The reaction proceeded under mild conditions in the presence of Co(OAc)2?4H2O as the catalyst and tolerates a wide range of both alcohols and benzamide substrates, including even olefinic carboxamides. In addition, this reaction is the first example of the direct alkoxylation of alkenes through C-H bond activation.