1417916-52-9

Basic information

• Product Name: Flupirtine DiMer
• Synonyms: Flupirtine DiMer;Flupirtine Maleate impurity D14461
• CAS NO: 1417916-52-9
• Molecular Formula: C₃₀H₃₂F₂N₈O₄
• Molecular Weight: 606.6230864
• Mol File: 1417916-52-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Flupirtine DiMer(CAS DataBase Reference)
• NIST Chemistry Reference: Flupirtine DiMer(1417916-52-9)
• EPA Substance Registry System: Flupirtine DiMer(1417916-52-9)

Safety Data

• Hazardous Substances Data: 1417916-52-9(Hazardous Substances Data)

Upstream product

• 1422275-80-6 ethyl {2-amino-5-bromo-6-[(4-fluorobenzyl)amino]-pyridin-3-yl}carbamate 
• 1422275-79-3 C₁₂H₁₂BrFN₄ 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 140-75-0 para-fluorobenzylamine 
• 33400-49-6 2-amino-3-nitro-6-(p-fluoro-benzylamino)-pyridine 
• 1422275-78-2 6-amino-2-(4-fluorobenzylamino)-3-bromo-5-nitropyridine 

Relevant articles and documents

Isolation, structure, synthesis and cytotoxicity of an unprecedented flupirtine dimer

A previously unknown dimer of the well-established analgesic flupirtine has been found, and its structure was revealed by ESI-MS, NMR spectroscopy and an independent synthesis. Thus, starting from 2-amino-6-chloro-3-nitro-pyridine the target compound was obtained in a four-step synthesis. Key-step of this synthesis is a nickel-mediated aryl-aryl coupling. The dimer 4 did not show any cytotoxicity, and its IC50 values were > 30 μm for all six human cancer cell lines and mouse fibroblasts used in this study.