1421-07-4

Basic information

• Product Name: 5-Ethyl-5-(3-hydroxy-3-methylbutyl)barbituric acid
• Synonyms: 5-Ethyl-5-(3-hydroxy-3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;5-Ethyl-5-(3-hydroxy-3-methylbutyl)barbituric acid;Hydroxyamobarbital
• CAS NO: 1421-07-4
• Molecular Formula: C₁₁H₁₈N₂O₄
• Molecular Weight: 242.27
• Mol File: 1421-07-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 187-188 °C(Solv: water (7732-18-5))
• Appearance: /
• Density: 1.161g/cm³
• Refractive Index: 1.482
• PKA: 7.93±0.10(Predicted)
• CAS DataBase Reference: 5-Ethyl-5-(3-hydroxy-3-methylbutyl)barbituric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethyl-5-(3-hydroxy-3-methylbutyl)barbituric acid(1421-07-4)
• EPA Substance Registry System: 5-Ethyl-5-(3-hydroxy-3-methylbutyl)barbituric acid(1421-07-4)

Safety Data

• Hazardous Substances Data: 1421-07-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H18N2O4/c1-4-11(6-5-10(2,3)17)7(14)12-9(16)13-8(11)15/h17H,4-6H2,1-3H3,(H2,12,13,14,15,16)

Upstream product

• 21149-88-2 5-ethyl-5-(3'-methylbut-2'-enyl) barbituric acid 
• 57-43-2 amobarbital 

Downstream Products

• 92215-62-8 acide ethyl-2 methyl-5 δ-caprolactone-2 carboxylique 
• 92215-61-7 allophanyl-2 ethyl-2 methyl-5 δ-caprolactone 
• 57-13-6 urea 

Relevant articles and documents

Relationship between polymorphism and bioavailability of amobarbital in the rabbit

The effect of the polymorphic form of amobarbital on its bioavailability was examined by measurement of the dissolution rate and in vivo absorption of two forms (Form I and Form II). The dissolution rate of Form II was faster than that of Form I. In in vivo absorption experiments using rabbits, two crystal forms of amobarbital were administered orally and the resulting blood time-level curves were compared with the dissolution rates. It appeared that the polymorphic form of the drug appreciably affected the absorption process from the digestive tract. Hydroxyamobarbital was confirmed to be the main metabolite of amobarbital.