92215-61-7Relevant articles and documents
δ-Lactonisation of γ-hydroxyamobarbital possible in vitro, impossible in vivo
Cave,Lafont,Lambrey,et al.
, p. 243 - 247 (2007/10/02)
δ-lactonization of γ-hydroxyamobarbital 1 was considered impossible. If it is true under biomimetic conditions, it bcomes possible in basic medium at 70-80° C. With sodium hydroxide, in aqueous solution. Two δ-lactonic compounds are obtained. With tetrabutylammonium hydroxide and chloroform different δ-lactonic structures are isolated. In vivo, in rats or in dogs, compound 1 does not undergo any δ-lactonization.