142102-79-2

Basic information

• Product Name: 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)
• Synonyms: 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)
• CAS NO: 142102-79-2
• Molecular Formula: C₂₅H₄₅N₃O₈SSi₂
• Molecular Weight: 603.8761
• Mol File: 142102-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 611.7°Cat760mmHg
• Flash Point: 323.7°C
• Appearance: /
• Density: 1.22g/cm³
• CAS DataBase Reference: 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)(142102-79-2)
• EPA Substance Registry System: 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)(142102-79-2)

Safety Data

• Hazardous Substances Data: 142102-79-2(Hazardous Substances Data)

Usage

Description

1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) is a nucleoside analogue with potential antiviral activity. It is composed of a ribonucleoside analog connected to a spirocyclopropyl oxathiole dioxide, which includes a thymine base and a methyl group. 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) has been investigated for its use in antiviral therapy, particularly against DNA viruses, by inhibiting viral DNA replication and acting as a chain terminator during viral DNA synthesis.

Uses

Used in Antiviral Applications:
1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) is used as an antiviral agent for its potential to combat DNA viruses. 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) works by inhibiting viral DNA replication, acting as a chain terminator during the synthesis process. This makes it a promising candidate for the development of new antiviral therapies.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) is used as a subject of research for understanding its mechanism of action and potential as an antiviral agent. Further studies are necessary to fully comprehend its capabilities and optimize its use in antiviral drug development.
Please note that the provided materials do not specify any other industries or applications for this compound. The information given is focused on its potential use in antiviral therapy and pharmaceutical research.

Upstream product

• 141781-17-1 2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine 
• 74-88-4 methyl iodide 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 
• 141781-18-2 <1-(β-D-ribofuranosyl)thymine>-3'-spiro-5''-<4''-amino-1'',2''-oxathiole 2'',2''-dioxide> 
• 250588-64-8 Benzoic acid (3aR,5R,6R,6aR)-6-cyano-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 142131-02-0 5-O-benzoyl-3-C-cyano-1,2-O-isopropylidene-3-O-mesyl-α-D-ribofuranose 
• 151215-43-9 1,2-di-O-acetyl-5-O-benzoyl-3-C-cyano-3-O-mesyl-D-ribofuranose 
• 142102-71-4 1-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)thymine 
• 142102-74-7 <1-(2'-O-acetyl-5'-O-benzoyl-β-D-ribofuranosyl)thymine>-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) 

Downstream Products

• 378748-06-2 [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-(methyl)thymine]-3'-spiro-5''-[4''-(3-benzoylureido)-1'',2''-oxathiole-2'',2''-dioxide] 
• 1039540-21-0 [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-benzylureido)-1'',2''-oxathiole-2'',2''-dioxide] 
• 1039540-07-2 [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide] 
• 1039540-14-1 [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-5''-[4''-(3-phenylcarboxamide-3-phenylureido)-1'',2''-oxathiole-2'',2''-dioxide] 

Relevant articles and documents

TSAO derivatives: Highly specific inhibitors of human immunodeficiency virus type-1 (HIV-1) replication

TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as th