14213-11-7

Basic information

• Product Name: 1-Nitro-4-(1H-tetrazole-1-yl)benzene
• Synonyms: 1-(4-Nitrophenyl)-1H-tetrazole;1-Nitro-4-(1H-tetrazole-1-yl)benzene
• CAS NO: 14213-11-7
• Molecular Formula: C₇H₅N₅O₂
• Molecular Weight: 191.1469
• Mol File: 14213-11-7.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 391.9°Cat760mmHg
• Flash Point: 190.8°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 2.38E-06mmHg at 25°C
• Refractive Index: 1.753
• CAS DataBase Reference: 1-Nitro-4-(1H-tetrazole-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Nitro-4-(1H-tetrazole-1-yl)benzene(14213-11-7)
• EPA Substance Registry System: 1-Nitro-4-(1H-tetrazole-1-yl)benzene(14213-11-7)

Safety Data

• Hazardous Substances Data: 14213-11-7(Hazardous Substances Data)

Usage

General Description

1-Nitro-4-(1H-tetrazole-1-yl)benzene, also known as Nitro-Tetrazole-Amine (NTA), is a chemical compound with the molecular formula C7H5N5O2. It is a yellow crystalline solid, with the nitro group and tetrazole ring providing unique properties for use in various applications. NTA is primarily used as a precursor for the synthesis of explosives, propellants, and pyrotechnic materials due to its high energy content. It is also used as a starting material for pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, NTA shows potential use in materials science, including as a building block for the construction of energetic materials and coordination polymers. However, its production, handling, and use require strict adherence to safety protocols due to its explosive nature.

InChI:InChI=1/C7H5N5O2/c13-12(14)7-3-1-6(2-4-7)11-5-8-9-10-11/h1-5H

Upstream product

• 186581-53-3 diazomethane 
• 100-05-0 4-nitrobenzenediazonium chloride 
• 5378-52-9 phenyl-1H-tetrazole 
• 555-16-8 4-nitrobenzaldehdye 
• 100-01-6 4-nitro-aniline 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 1984-23-2 p-nitrophenyl isocyanide 
• 16135-31-2 p-nitroformanilide 
• 26060-36-6 N-(4-nitrophenyl)methanethioamide 
• 288-94-8 1H-tetrazole 
• 350-46-9 4-Fluoronitrobenzene 
• 4648-54-8 trimethylsilylazide 
• 62-53-3 aniline 

Downstream Products

• 61700-60-5 N-(4-nitrophenyl)cyanamide 
• 14213-13-9 4-tetrazol-1-yl-phenylamine 
• 135220-03-0 Dimethyl-[1-(4-nitro-phenyl)-1H-tetrazol-5-ylmethyl]-amine 
• 112777-78-3 N-<(4-Nitro)phenyl>-N'-methylcarbodiimide 
• 49579-70-6 1-(4-nitrophenyl)-1H-tetrazol-5-amine 
• 98550-37-9 N-(4-nitrophenyl)-1H-tetrazol-5-amine 
• 1026190-86-2 N-((tert-butylimino)methylene)-4-nitroaniline 
• 217654-45-0 phenyl 4-(1H-1-tetrazolyl)phenylcarbamate 
• 181869-53-4 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-(1H,3H)-imidazolone 
• 181869-54-5 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone 
• 217654-62-1 1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea 
• 217654-58-5 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea 
• 217654-54-1 1-(2,2-diethoxyethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea 
• 97954-62-6 N,N’-(1,4-phenylene)dicyanamide 

Relevant articles and documents

Salen complex of Cu(II) supported on superparamagnetic Fe3O 4@SiO2 nanoparticles: An efficient and recyclable catalyst for synthesis of 1- and 5-substituted 1H-tetrazoles

An efficient and general method has been developed for synthesis of 1- and 5-substituted 1H-tetrazoles from nitriles and amines using magnetite nanoparticles immobilized Salen Cu(II) as an efficient and recyclable catalyst. The structural and magnetic properties of functionalized magnetic silica are identified by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM) instruments. NMR, FT-IR, elemental analysis and XRD were also used for identification of these structures. Nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least 7 times with less deterioration in catalytic activity.

Copper coordinated-poly(α-amino acid) decorated on magnetite graphene oxide as an efficient heterogeneous magnetically recoverable catalyst for the selective synthesis of 5- and 1-substituted tetrazoles from various sources: A comparative study

In this work, poly(α-amino acid)-Cu(II) complex immobilized on magnetite graphene oxide (GO/Fe3O4?PAA-Cu-complex) was prepared via a multistep synthesis and employed as an efficient, heterogeneous, magnetically recyclable nanocatalyst for one-pot, three component synthesis of 5- and 1-substituted tetrazoles using different substrates including benzaldehydes, benzonitriles, and anilines in mild conditions. The different approaches were mechanically investigated and compared. The catalyst was fully characterized by Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), energy dispersive X-ray spectroscopy (EDX), inductively coupled plasma (ICP), FE-SEM and TEM analyses. The magnetic nanocatalyst could be readily separated from the reaction mixture by an external magnet and reused for several times without significant loss of catalytic activity. Also, the spectroscopic analysis revealed the stability and durability of the catalyst. Finally, the chemoselectivity of the method was investigated by the various combinations of aldehyde, nitrile, and oxime.

One pot three component solvent free synthesis of N-substituted tetrazoles using RuO2 /MMT catalyst

A facile, one-pot three component catalytic method is developed for the synthesis of N-substituted tetrazole using RuO2/MMT nanocomposite. It is characterized with low and wide angle XRD which suggests that RuO2 nanoparticles are evenly dispersed on the surface of MMT while FESEM images indicate a spherical morphology having size in the range of 40-50 nm. The catalytic efficiency is evaluated for three component one-pot synthesis of the tetrazole using various amine, sodium azide and triethyl-ortho-formate under solvent free condition. This strategy has resulted in good to excellent yields (84 – 97percent) of N-substituted tetrazoles within moderate reaction time. Moreover, the catalyst possesses excellent reusability up to five cycles with only 5percent decrease in the yield of tetrazole after 5th cycle. The beneficial catalytic activity of the bifunctional nanocomposite is attributed to the uniformly dispersed RuO2 nanoparticles on the surface of MMT where RuO2 site is responsible for coordination of isocyanide intermediate while strong acidic character of MMT induces condensation and cyclization steps in a synergic manner. Thus, it can be argued that RuO2/MMT nanocomposite possesses potential applications for Multi Component Reactions (MCR) in terms of efficient and sustainable manner.

The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route

Today, most synthetic methods are aimed at carrying out reactions under more efficient conditions and the realization of the twelve principles of green chemistry. Due to the importance and widespread applications of tetrazoles in various industries, especially in the field of pharmaceutical chemistry, and the expansion of the use of nanocatalysts in the preparation of valuable chemical reaction products, we decided to use an (Fe3O4@NFC@NSalophCu)CO2H nanocatalyst in this project. In this study, the synthesis of the nanocatalyst (Fe3O4@NFC@NSalophCu)CO2H was explained in a step-by-step manner. Confirmation of the structure was obtained based on FT-IR, EDX, FE-SEM, TEM, XRD, VSM, DLS, TGA, H-NMR, and CHNO analyses. The catalyst was applied to the synthesis of 5-substituted-1H-tetrazole and 1-substituted-1H-tetrazole derivatives through multi-component reactions (MCRs), and the performance was assessed. With advances in science and technology and increasing environmental pollution, the use of reagents and methods that are less dangerous for the environment has received much attention. Therefore, following green chemistry principles, with the help of the (Fe3O4@NFC@NSalophCu)CO2H salen complex as a nanocatalyst that is recyclable, cheap, safe, and available, the use of water as a green solvent, and reduced reaction times, the synthesis of tetrazoles can be achieved.

Practical synthesis of tetrazoles from amides and phosphorazidates in the presence of aromatic bases

Tetrazoles were effectively synthesized from amides using diphenyl phosphorazidate or bis(p-nitrophenyl) phosphorazidate in the presence of aromatic bases. Various amides underwent the proposed cycloaddition reaction to provide the corresponding tetrazoles. Studies on the racemization of chiral substrates were also performed. Overall, the proposed synthesis method enables the preparation of 1,5-disubstituted and 1-substituted tetrazoles, and 5-substituted 1H-tetrazoles without using toxic or explosive reagents.

Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst for the Synthesis of Tetrazoles Under Visible Light Irradiation

Abstract: Herein, a polymer supported Fe-Phthalocyanine entangled with carboxyl functionalized benzimidazolium moiety (PSFePcCFBM) explored as heterogenous photocatalyst, for regioselective synthesis of 1H-tetrazoles from sodium azide and other affordable