49579-70-6

Basic information

• Product Name: 1H-Tetrazol-5-amine, 1-(4-nitrophenyl)-
• CAS NO: 49579-70-6
• Molecular Formula: C7H6N6O2
• Molecular Weight: 206.164
• Mol File: 49579-70-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazol-5-amine, 1-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazol-5-amine, 1-(4-nitrophenyl)-(49579-70-6)
• EPA Substance Registry System: 1H-Tetrazol-5-amine, 1-(4-nitrophenyl)-(49579-70-6)

Safety Data

• Hazardous Substances Data: 49579-70-6(Hazardous Substances Data)

Usage

Structure

A compound consisting of a tetrazole ring with a nitrophenyl group attached to it.

Usage

Often used as a building block for the synthesis of pharmaceuticals and other organic compounds.

Applications

Potential applications in the field of medicinal chemistry, particularly in the development of new drugs and therapies.

Relevance

Unique structure and reactivity make it a valuable intermediate in the synthesis of heterocyclic compounds and other complex organic molecules.

Utility

Nitrophenyl group makes it a useful reagent for chemical reactions and transformations.

Industry significance

Significant potential for use in various research and industrial applications in the pharmaceutical and chemical industries.

Upstream product

• 61700-60-5 N-(4-nitrophenyl)cyanamide 
• 3696-22-8 p-nitrophenylthiourea 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 4418-61-5 5-aminotetrazole 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 1984-23-2 p-nitrophenyl isocyanide 
• 16135-31-2 p-nitroformanilide 
• 98550-37-9 N-(4-nitrophenyl)-1H-tetrazol-5-amine 
• 107-21-1 ethylene glycol 
• 5467-78-7 fenamole 
• 100-01-6 4-nitro-aniline 
• 14213-11-7 1-(4-nitrophenyl)-1H-tetrazole 

Downstream Products

• 1266401-64-2 1-(1-adamantyl)-5-amino-4-(4-nitrophenyl)tetrazol-1-ium perchlorate 
• 101724-63-4 N-(methyl-[1,3,4]oxadiazol-2-yl)-N-(4-nitro-phenyl)-acetamide 
• 98550-37-9 N-(4-nitrophenyl)-1H-tetrazol-5-amine 
• 114698-69-0 1-(4-amino-phenyl)-1H-tetrazol-5-ylamine 
• 108106-15-6 N-[1-(4-nitro-phenyl)-1H-tetrazol-5-yl]-acetamide 
• 108106-93-0 (methyl-[1,3,4]oxadiazol-2-yl)-(4-nitro-phenyl)-amine 

Relevant articles and documents

Functionalization of chitosan by grafting Cu(II)-5-amino-1H-tetrazole complex as a magnetically recyclable catalyst for C-N coupling reaction

The functionalization of chitosan (as a linear polysaccharide) with a copper complex to expand the areas of its potential applications is an important scientific task. The present work reports the application of Cu(II)-5-amino-1H-tetrazole complex immobilized on modified magnetic chitosan as an effective catalyst (Fe3O4@Chitosan-Tet-Cu(II)) for C-N bond cross-coupling reaction between 5-aminotetrazole and aryl halides under ligand-free conditions in dioxane solvent. The prepared magnetic nanocatalyst was characterized by FT-IR, EDS, TEM, HRTEM, VSM, FFT, XRD, TG-DTG, ICP-MS, and elemental mapping analyses. 1-Aryl-5-amino-1H-tetrazoles were produced in high yields. The advantages of this catalytic process include simple methodology, avoiding the use of harmful catalysts, short reaction times, excellent yields, easy work-up, and environmentally friendly conditions. Fe3O4@Chitosan-Tet-Cu(II) catalyst exhibited high efficacy and reusability/recyclability even after seven consecutive cycles with low loss of catalytic activity.

Eco-efficient one-pot tandem synthesis of 1-aryl-1H-tetrazol-5-amine by CAN via in situ generated 1-phenylthiourea and heterocumulene

A simple, cost-effective, environmentally benign, and efficient one-pot tandem approach to the synthesis of pharmaceutically important 1-aryl-1H-tetrazole-5-amines 3a-k and 4a-k has been described. The reaction utilized 1-phenyl thiourea, which was generated in situ from aqueous ammonia and isocyanates 1a-k, for the formation of heterocumenes using sodium azide, triethylamine, and ceric ammonium nitrate (CAN) to obtain various aryl-substituted 1H-tetrazole-5-amines (3a-k) in good to excellent yields.

A versatile synthesis of arylaminotetrazoles by a magnetic Fe@Phendiol@Mn nano-particle catalyst and its theoretical studies

The Fe3O4 magnetic nano-particles were modified with 1,10-phenanthroline-5,6-diol and the relevant Mn complex (Fe@Phendiol@Mn) synthesized as a nano-magnetic heterogeneous catalyst to be used for the synthesis of various arylaminotet