1422148-82-0Relevant articles and documents
EZH2 Inhibitors
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Paragraph 0154; 0155, (2018/11/02)
The present invention relates to compounds that inhibit EZH2 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles
Jhan, Yu-Huei,Kang, Ting-Wei,Hsieh, Jen-Chieh
supporting information, p. 1155 - 1159 (2013/03/13)
An efficient copper-catalyzed intramolecular N-arylation was performed by using substituted 2-(2-bromoaryl)acetamide with a small amount of Cu 2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields of oxindoles with tolerance of a wide variety of substrates.